It has been more than a century since Pío del Río‐Hortega first characterized microglia in
histological stains of brain tissue. Since then, significant advances have been made in …

Traumatic brain injury (TBI) is a public health burden affecting millions of people. Sustained
neuroinflammation after TBI is often associated with poor outcome. As a result, increased …

Neuroinflammation is a key driver of neurodegenerative disease, however the tools
available to model this disease biology at the systems level are lacking. We describe a …

Reactive microglia are a hallmark of age-related retinal degenerative diseases including
age-related macular degeneration (AMD). These cells are capable of secreting neurotoxic …

Cisplatin is a widely used anticancer drug with notable side effects including ototoxicity and
nephrotoxicity. Macrophages, the major resident immune cells in the cochlea and kidney …

Retinal detachment (RD) is a sight-threatening condition that occurs in several retinal
diseases. Microglia that reside in retina are activated after RD and are involved in the death …

Spinal cord injury is a complicated medical condition both from the clinician's point of view in
terms of management and from the patient's perspective in terms of unsatisfactory recovery …

Microglia are innate CNS immune cells that play key roles in supporting key CNS functions
including brain plasticity. We now report a previously unknown role for microglia in …

Background Rodent models for perinatal hypoxic ischemic (HI) encephalopathy have
reported sex differences such as the same injury causing larger lesions in the brains of …