While having tremendous potential as therapeutic and imaging tools, the clinical use of
engineered nanoparticles has been associated with serious safety concerns. Activation of …

After a delay of roughly 30 years, liposomes are becoming important as drug-targeting
systems especially in anticancer therapy. Two liposomal anthracycline formulations are now …

Delivery is the major obstacle to success of nucleic-acid-based therapies. We have
neutralized DNA with a cationic detergent (C12CCP) obtained by amide bond formation …

We have recently reported that PEGylated liposomes (PL) are cleared rapidly from the blood
circulation when they are administered twice in the same rat at certain intervals, even if the …

Colloidal and interfacial phenomena lie at the core of drug formulation, drug delivery, as well
as drug binding and action at diseased sites, eg, in cancer therapy. We review a class of …

[57] ABSTRACT A method for preparing encapsulated lipid-bilayer materials in a silica
matrix comprising preparing a silica sol, mixing a lipid-bilayer material in the silica sol and …

The complement system is one of the most ancient defense strategies, which serves as an
important effector arm of both innate and acquired immunity. Three consequences ensue …

Liposomal formulation of siRNA is an attractive approach for improving its delivery in vivo,
shielding the RNA from nucleases and promoting tumor targeting. Here, the production of …

Microbubble‐enabled focused ultrasound (MB‐FUS) has revolutionized nano and molecular
drug delivery capabilities. Yet, the absence of longitudinal, systematic, quantitative studies of …

Most of DNA synthetic complexes result from the self-assembly of DNA molecules with
cationic lipids or polymers in an aqueous controlled medium. However, injection of such self …