The emergence and global spread of bacterial resistance to conventionally used antibiotics
have highlighted the urgent need for new antimicrobial agents that might replace antibiotics …

The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

BACKGROUND Antibiotics are among the most important tools in medicine, but their efficacy
is threatened by the evolution of resistance. Since the earliest days of antibiotics, resistance …

The development of highly effective conjugate chemistry approaches is a way to improve the
quality of drugs and of medicines. The aim of this paper is to highlight and review such …

The burden of multidrug resistance in Gram-negative bacilli (GNB) now represents a daily
issue for the management of antimicrobial therapy in intensive care unit (ICU) patients. In …

Objectives In 2017, the World Health Organization (WHO) published a list of global priority
pathogens (GPP)–12 species of bacteria with critical, high, and medium antibiotic resistance …

Colistin (Polymyxin E) is one of the few cationic antimicrobial peptides commercialized in
both human and veterinary medicine. For several years now, colistin has been considered …

The global incidence of drug-resistant Gram-negative bacillary infections has been
increasing, and there is a dire need to develop novel strategies to overcome this problem …

The massive consumption of antibiotics in the ICU is responsible for substantial ecological
side effects that promote the dissemination of multidrug-resistant bacteria (MDRB) in this …

Infections caused by resistant gram‐negative bacteria are becoming increasingly prevalent
and now constitute a serious threat to public health worldwide because they are difficult to …