Antibiotic resistance is a critical global healthcare issue that urgently needs new effective
solutions. While small molecule antibiotics have been safeguarding us for nearly a century …

ABSTRACT Ceftazidime/avibactam (CAZ-AVI), approved in 2015, is an important first-line
option for KPC-producing Enterobacterales (KPC-E). Although still uncommon, resistance to …

With the antibiotic development pipeline running dry, many fear that we might soon run out
of treatment options. High-density infections are particularly difficult to treat due to their …

Antibiotic resistance is one of the greatest current threats to human health, and without
significant action we face the chilling prospect of a world without effective antibiotics …

Alternating antibiotic therapy, in which pairs of drugs are cycled during treatment, has been
suggested as a means to inhibit the evolution of de novo resistance while avoiding the …

Infections caused by carbapenemase-producing, multidrug-resistant (MDR), or extensively
drug-resistant (XDR) Gram-negative bacteria constitute a major therapeutic challenge …

Antimicrobial peptides (AMPs) are ancient and conserved across the tree of life. Their
efficacy over evolutionary time has been largely attributed to their mechanisms of killing. Yet …

Fever may be the only clinical symptom at the onset of infection in neutropenic cancer
patients undergoing myelosuppressive chemotherapy. A prompt and evidence-based …

CaCO 3 crystals have been known for a long time as naturally derived and simply fabricated
nano (micro)-sized materials able to effectively host and release various molecules. This …

Biofilm has garnered a lot of interest due to concerns in various sectors such as public
health, medicine, and the pharmaceutical industry. Biofilm-producing bacteria show a …