Lead discovery and chemical biology approaches targeting the ubiquitin proteasome system
FA Akinjiyan, S Carbonneau, NT Ross - Bioorganic & Medicinal Chemistry …, 2017 - Elsevier
Protein degradation is critical for proteostasis, and the addition of polyubiquitin chains to a
substrate is necessary for its recognition by the 26S proteasome. Therapeutic intervention in …
substrate is necessary for its recognition by the 26S proteasome. Therapeutic intervention in …
Proteome editing using engineered proteins that hijack cellular quality control machinery
N Lopez‐Barbosa, MB Ludwicki, MP DeLisa - AIChE Journal, 2020 - Wiley Online Library
Protein silencing is an important aspect of both scientific investigation of native protein
function and therapeutic targeting of aberrant protein activity. Many techniques for silencing …
function and therapeutic targeting of aberrant protein activity. Many techniques for silencing …