Acquired resistance inevitably limits the curative effects of epidermal growth factor receptor
tyrosine kinase inhibitors (EGFR-TKIs), which represent the classical paradigm of molecular …

Simple Summary Prostate cancer (PCa) affects millions of men globally, and approximately
20% of PCa patients are found after they develop into a lethal metastatic or castration …

Epidermal growth factor receptor (EGFR) is of great significance in mediating cell signaling
transduction and tumor behaviors. Currently, third-generation inhibitors of EGFR, especially …

Obesity is a risk factor for at least 13 different types of cancer, many of which are hormonally
driven, and is associated with increased cancer incidence and morbidity. Adult obesity rates …

The insulin-like growth factor 1 receptor (IGF-1R) governs several signaling pathways for
cell proliferation, survival, and anti-apoptosis. Thus, targeting IGF-1R appears as a …

There are currently no effective biomarkers for prognosis and optimal treatment selection to
improve non-small cell lung cancer (NSCLC) survival outcomes. This study further validated …

The insulin-like growth factor receptor (IGF-1R) was among the most intensively pursued
kinase targets in oncology. However, even after a slew of small-molecule and antibody …

Abstract The Pathogen Box is a 400‐strong collection of drug‐like compounds, selected for
their potential against several of the world's most important neglected tropical diseases …

Preclinical studies indicate that activated IGF‐1R can drive endocrine resistance in ER‐
positive (ER+) breast cancer, but its clinical relevance is unknown. We studied the effect of …

Non-small cell lung cancer (NSCLC) remains one of the deadliest malignant diseases, with
high incidence and mortality worldwide. The insulin-like growth factor (IGF) axis, consisting …