[HTML][HTML] Understanding addiction using animal models

BN Kuhn, PW Kalivas, AC Bobadilla - Frontiers in behavioral …, 2019 - frontiersin.org
Drug addiction is a neuropsychiatric disorder with grave personal consequences that has an
extraordinary global economic impact. Despite decades of research, the options available to …

From sign-tracking to attentional bias: Implications for gambling and substance use disorders

P Anselme, MJF Robinson - Progress in Neuro-Psychopharmacology and …, 2020 - Elsevier
Sign-tracking behavior in Pavlovian autoshaping is known to be a relevant index of the
incentive salience attributed to reward-related cues. Evidence has accumulated to suggest …

[HTML][HTML] Choose your path: Divergent basolateral amygdala efferents differentially mediate incentive motivation, flexibility and decision-making

SE Keefer, U Gyawali, DJ Calu - Behavioural Brain Research, 2021 - Elsevier
To survive in a complex environment, individuals form associations between environmental
stimuli and rewards to organize and optimize reward seeking behaviors. The basolateral …

The associative learning roots of affect-driven impulsivity and its role in problem gambling: A replication attempt and extension of Quintero et al.(2020)

I Muela, JM Ventura-Lucena, JF Navas… - Journal of behavioral …, 2023 - akjournals.com
Background and aims Negative/positive urgency (NU/PU) refers to the proneness to act
rashly under negative/positive emotions. These traits are proxies to generalized emotion …

Under the influence: Effects of adolescent ethanol exposure and anxiety on motivation for uncertain gambling-like cues in male and female rats

SN Hellberg, JD Levit, MJF Robinson - Behavioural Brain Research, 2018 - Elsevier
Gambling disorder (GD) frequently co-occurs with alcohol use and anxiety disorders,
suggesting possible shared mechanisms. Recent research suggests reward uncertainty may …

Sign tracking predicts suboptimal behavior in a rodent gambling task

M Swintosky, JT Brennan, C Koziel, JP Paulus… - …, 2021 - Springer
Rationale Reward-associated cues can promote maladaptive behavior, including risky
decision-making in a gambling setting. A propensity for sign tracking over goal tracking—ie …

Pharmacological evidence that 5-HT2C receptor blockade selectively improves decision making when rewards are paired with audiovisual cues in a rat gambling …

WK Adams, C Barkus, JMN Ferland, T Sharp… - …, 2017 - Springer
Rationale Adding reward-concurrent cues to a rat gambling task (rGT) increases risky
choice. This cued version of the task may reflect an “addiction-like” cognitive process, more …

Distinguishing between predictive and incentive value of uncertain gambling-like cues in a Pavlovian autoshaping task

MJF Robinson, C Clibanoff, CM Freeland… - Behavioural Brain …, 2019 - Elsevier
The flashing lights and celebratory sounds that dominate slot-machine gambling are
believed to promote engagement and motivation to keep playing. However, these cues are …

[HTML][HTML] Alter game: A study protocol on a virtual “serious game” for relapse prevention in patients with gambling disorder

R Giordano, MA Donati, L Zamboni, F Fusina… - Frontiers in …, 2022 - frontiersin.org
Cognitive behavioral therapy (CBT) is the most successful protocol in gambling disorder
(GD) treatment. However, it presents some weaknesses, especially concerning relapse …

[HTML][HTML] Propensity for risky choices despite lower cue reactivity in adolescent rats

S Zeng, EFB McLaughlin, A Ramesh… - Frontiers in Behavioral …, 2023 - ncbi.nlm.nih.gov
Adolescence is a time of heightened risk-taking across species. Salient audiovisual cues
associated with rewards are a common feature of gambling environments and have been …