Lung cancer has the highest mortality rate of all cancers worldwide. Lung cancer is a very
heterogeneous disease that is often diagnosed at later stages which have a poor prognosis …

Mechanisms of leukemia translocations : Current Opinion in Hematology Mechanisms of
leukemia translocations : Current Opinion in Hematology Log in or Register Subscribe to …

New tailored copper (II)–based intercalating complexes [Cu (L 1) 2](1) and [Cu (L 2) 2](2)
were synthesized from Schiff base scaffold HL 1 and HL 2 (E)-4-(2-((2-hydroxy-3 …

Herein, we report the synthesis and single crystal X-ray structure of Cu (II)-picolinic acid
complex, 1 as a potent topoisomerase I inhibitor. The complex 1 crystallized in the triclinic …

DNA topoisomerase I (Topo I) is a molecular target for the anticancer agent topotecan in the
treatment of small cell lung cancer and ovarian carcinomas. However, the molecular …

Topoisomerase I (topo I) is an important target for the treatment of malignant disease,
especially colorectal cancer. Because there is little information on the expression of topo I in …

New chiral L-/d-valine-quercetin diorganotin (IV) complexes [(CH 3) 2 Sn (Q)(val)] 1 L/D,[(C
6 H 5) 2 Sn (Q)(val)] 2 L/D, were synthesized and thoroughly characterized by elemental …

In this study, we used array‐comparative genomic hybridization (aCGH) and fluorescent in
situ hybridization (FISH) to examine genetic aberrations in melanoma cell lines and tissues …

Cancer is still the number two cause of death in highly developed countries. Due to
increased life expectancy, the number of cancer cases has also increased, and it is not likely …

Em Portugal, o cancro do pulmão é a principal causa de morte entre as neoplasias. Em
2006 são previstos mais de 3500 novos casos, dos quais 20% serão diagnosticados como …