Alternative splicing in lung cancer
Lung cancer has the highest mortality rate of all cancers worldwide. Lung cancer is a very
heterogeneous disease that is often diagnosed at later stages which have a poor prognosis …
heterogeneous disease that is often diagnosed at later stages which have a poor prognosis …
Mechanisms of leukemia translocations
JA Nickoloff, LP De Haro, J Wray… - Current opinion in …, 2008 - journals.lww.com
Mechanisms of leukemia translocations : Current Opinion in Hematology Mechanisms of
leukemia translocations : Current Opinion in Hematology Log in or Register Subscribe to …
leukemia translocations : Current Opinion in Hematology Log in or Register Subscribe to …
Structure elucidation {spectroscopic, single crystal X-ray diffraction and computational DFT studies} of new tailored benzenesulfonamide derived Schiff base copper (II …
Z Afsan, T Roisnel, S Tabassum, F Arjmand - Bioorganic Chemistry, 2020 - Elsevier
New tailored copper (II)–based intercalating complexes [Cu (L 1) 2](1) and [Cu (L 2) 2](2)
were synthesized from Schiff base scaffold HL 1 and HL 2 (E)-4-(2-((2-hydroxy-3 …
were synthesized from Schiff base scaffold HL 1 and HL 2 (E)-4-(2-((2-hydroxy-3 …
Molecular docking, DFT and antimicrobial studies of Cu (II) complex as topoisomerase I inhibitor
Herein, we report the synthesis and single crystal X-ray structure of Cu (II)-picolinic acid
complex, 1 as a potent topoisomerase I inhibitor. The complex 1 crystallized in the triclinic …
complex, 1 as a potent topoisomerase I inhibitor. The complex 1 crystallized in the triclinic …
DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation
A Mialon, M Sankinen, H Söderström… - … and cellular biology, 2005 - Taylor & Francis
DNA topoisomerase I (Topo I) is a molecular target for the anticancer agent topotecan in the
treatment of small cell lung cancer and ovarian carcinomas. However, the molecular …
treatment of small cell lung cancer and ovarian carcinomas. However, the molecular …
Topoisomerase I protein expression in primary colorectal cancer and lymph node metastases
A Boonsong, S Curran, JA Mckay, J Cassidy, GI Murray… - Human pathology, 2002 - Elsevier
Topoisomerase I (topo I) is an important target for the treatment of malignant disease,
especially colorectal cancer. Because there is little information on the expression of topo I in …
especially colorectal cancer. Because there is little information on the expression of topo I in …
Human topoisomerase I mediated cytotoxicity profile of l-valine-quercetin diorganotin (IV) antitumor drug entities
S Parveen, S Tabassum, F Arjmand - Journal of Organometallic Chemistry, 2016 - Elsevier
New chiral L-/d-valine-quercetin diorganotin (IV) complexes [(CH 3) 2 Sn (Q)(val)] 1 L/D,[(C
6 H 5) 2 Sn (Q)(val)] 2 L/D, were synthesized and thoroughly characterized by elemental …
6 H 5) 2 Sn (Q)(val)] 2 L/D, were synthesized and thoroughly characterized by elemental …
Topoisomerase I amplification in melanoma is associated with more advanced tumours and poor prognosis
D Ryan, M Rafferty, S Hegarty… - Pigment cell & …, 2010 - Wiley Online Library
In this study, we used array‐comparative genomic hybridization (aCGH) and fluorescent in
situ hybridization (FISH) to examine genetic aberrations in melanoma cell lines and tissues …
situ hybridization (FISH) to examine genetic aberrations in melanoma cell lines and tissues …
New targets and drugs in cancer chemotherapy
T Szekeres, L Novotny - Medical Principles and Practice, 2002 - karger.com
Cancer is still the number two cause of death in highly developed countries. Due to
increased life expectancy, the number of cancer cases has also increased, and it is not likely …
increased life expectancy, the number of cancer cases has also increased, and it is not likely …
Carcinoma do pulmão de pequenas células–Estado da arte e perspectivas futuras
FJ Barata, AF Costa - Revista Portuguesa de Pneumologia (English Edition …, 2007 - Elsevier
Em Portugal, o cancro do pulmão é a principal causa de morte entre as neoplasias. Em
2006 são previstos mais de 3500 novos casos, dos quais 20% serão diagnosticados como …
2006 são previstos mais de 3500 novos casos, dos quais 20% serão diagnosticados como …