Bone metabolism in obesity and weight loss

SA Shapses, D Sukumar - Annual review of nutrition, 2012 - annualreviews.org
Excess body weight due to obesity has traditionally been considered to have a positive
effect on bone; however, more recent findings suggest that bone quality is compromised …

Obesity and fracture in men and women: an epidemiologic perspective

CM Nielson, P Srikanth, ES Orwoll - Journal of bone and mineral …, 2012 - academic.oup.com
In Western societies, mean body weight has increased dramatically in older people, and a
similar trend exists in Asia. Yet insufficient attention has been directed to the problem of …

Prevalence of vitamin D deficiency among overweight and obese US children

CB Turer, H Lin, G Flores - Pediatrics, 2013 - publications.aap.org
OBJECTIVE: Adequate vitamin D is essential for skeletal health in developing children.
Although excess body weight is associated with risk of vitamin D deficiency, the national …

Obesity is a risk factor for fracture in children but is protective against fracture in adults: a paradox

P Dimitri, N Bishop, JS Walsh, R Eastell - Bone, 2012 - Elsevier
With the rise in obesity worldwide, an important debate has developed as to whether excess
fat has a detrimental or protective effect on skeletal health in children and adults. Obese …

Childhood obesity, bone development, and cardiometabolic risk factors

NK Pollock - Molecular and cellular endocrinology, 2015 - Elsevier
Osteoporosis and obesity are both major public health concerns. It has long been
considered that these are distinct disorders rarely found in the same individual; however …

An epidemiological evaluation of pediatric long bone fractures—a retrospective cohort study of 2716 patients from two Swiss tertiary pediatric hospitals

A Joeris, N Lutz, B Wicki, T Slongo, L Audigé - BMC pediatrics, 2014 - Springer
Background Children and adolescents are at high risk of sustaining fractures during growth.
Therefore, epidemiological assessment is crucial for fracture prevention. The AO …

A randomized controlled trial of dance exergaming for exercise training in overweight and obese adolescent girls

AE Staiano, AM Marker, RA Beyl, DS Hsia… - Pediatric …, 2017 - Wiley Online Library
Background Structured exergaming with prescribed moderate intensity physical activity has
reduced adiposity among adolescents. The extent to which adolescents reduce adiposity …

Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice

GV Halade, A El Jamali, PJ Williams, RJ Fajardo… - Experimental …, 2011 - Elsevier
Clinical evidence indicates that fat is inversely proportional to bone mass in elderly obese
women. However, it remains unclear whether obesity accelerates bone loss. In this report …

High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment

L Shu, E Beier, T Sheu, H Zhang, MJ Zuscik… - Calcified tissue …, 2015 - Springer
Obesity is a severe health problem in children, afflicting several organ systems including
bone. However, the role of obesity on bone homeostasis and bone cell function in children …

Regulation of early adipose commitment by Zfp521

S Kang, P Akerblad, R Kiviranta, RK Gupta… - PLoS …, 2012 - journals.plos.org
While there has been significant progress in determining the transcriptional cascade
involved in terminal adipocyte differentiation, less is known about early events leading to …