Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of
the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of …

Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are suggested to be
responsible for drug resistance and cancer relapse due in part to their ability to self‐renew …

Drug resistance represents one of the greatest challenges in cancer treatment. Cancer stem
cells (CSCs), a subset of cells within the tumor with the potential for self-renewal …

Chemoresistant metastatic relapse of minimal residual disease plays a significant role for
poor prognosis of cancer. Growing evidence supports a critical role of cancer stem cell …

Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Similar to normal tissue, many tumors have a hierarchical organization where tumorigenic
cancer stem cells (CSCs) differentiate into non-tumorigenic progenies. A host of studies …

Drug resistance is the main culprit of failure in cancer therapy that may lead to cancer
relapse. This resistance mostly originates from rare, but impactful presence of cancer stem …

Anti–vascular endothelial growth factor (VEGF) therapy has failed to improve survival in
patients with breast cancer (BC). Potential mechanisms of resistance to anti-VEGF therapy …

Micro RNA s (mi RNA s) are small non‐coding RNA s that regulate gene expression at a
post‐transcriptional level via either the degradation or translational repression of a target …

Natural products or nutraceuticals have been shown to elicit anti-aging, anti-cancer and
other health-enhancing effects. A key target of the effects of natural products may be the …