Significance: Alzheimer disease (AD) is an all-too-common condition in the aging
population. However, aging does not automatically equal neurodegeneration and memory …

Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …

The nervous system and the immune system both rely on an extensive set of modalities to
perceive and act on perturbations in the internal and external environments. During feeding …

Oxidative stress and autophagy play essential roles in the development of senile
osteoporosis which is characterized by disrupted osteoclastic bone resorption and …

Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n) are essential regulatory
signaling molecules generated by the entire body, including the central nervous system …

Neurogenesis occurs in the brain during embryonic development and throughout adulthood.
Neurogenesis occurs in the hippocampus and under normal conditions and persists in two …

Flavonoids are a biodiverse family of dietary compounds that have antioxidant, anti-
inflammatory, antiviral, and antibacterial cell protective profiles. They have received …

In this research, we compared the cognitive parameters of 2-, 7-, and 15-month-old mice,
changes in mitochondrial DNA (mtDNA) integrity and expression of genes involved in the …

The retinal pigment epithelium (RPE) performs a range of necessary functions within the
neural layers of the retina and helps ensure vision. The regulation of pro-oxidative and …

The purified polysaccharides from Hericium erinaceus fermented mycelium entitled with
PHEB was analyzed and it was mainly composed of six glycosidic bonds. It has been …