Overview of PM2. 5 and health outcomes: focusing on components, sources, and pollutant mixture co-exposure

N Nan, Z Yan, Y Zhang, R Chen, G Qin, N Sang - Chemosphere, 2023 - Elsevier
PM 2.5 varies in source and composition over time and space as a complicated mixture.
Consequently, the health effects caused by PM 2.5 varies significantly over time and …

Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances

Z Yu, C Xu, B Song, S Zhang, C Chen, C Li… - Journal of Translational …, 2023 - Springer
Cancer remains the leading cause of death around the world. In cancer treatment, over 50%
of cancer patients receive radiotherapy alone or in multimodal combinations with other …

[HTML][HTML] Diesel exhaust PM2. 5 greatly deteriorates fibrosis process in pre-existing pulmonary fibrosis via ferroptosis

D Yue, Q Zhang, J Zhang, W Liu, L Chen… - Environment …, 2023 - Elsevier
Abstract Fine particulate matter (PM2. 5) has been widely reported to contribute to the
pathogenesis of pulmonary diseases. The direct hazardous effect of PM2. 5 on the …

Non-coding RNAs: an emerging player in particulate matter 2.5-mediated toxicity

SM Aghaei-Zarch, I Alipourfard, H Rasoulzadeh… - International journal of …, 2023 - Elsevier
Exposure to air pollution has been connected to around seven million early deaths annually
and also contributing to higher than 3% of disability-adjusted lost life years. Particulate …

Activation of Nrf2 signalling pathway by tectoridin protects against ferroptosis in particulate matter‐induced lung injury

T Dong, X Fan, N Zheng, K Yan, T Hou… - British Journal of …, 2023 - Wiley Online Library
Background and Purpose Our previous research showed that ferroptosis plays a crucial role
in the pathophysiology of PM2. 5‐induced lung injury. The present study aimed to …

Fibroblast-derived CXCL14 aggravates crystalline silica–induced pulmonary fibrosis by mediating polarization and recruitment of interstitial macrophages

Y You, H Yuan, H Min, C Li, J Chen - Journal of Hazardous Materials, 2023 - Elsevier
Exposure to crystalline silica (CS) particles in worksites and dwellings can lead to silicosis
due to excessive fibroblast activation. Considering their immuno-regulatory activities, the …

[HTML][HTML] FDX1 regulates leydig cell ferroptosis mediates PM2. 5-induced testicular dysfunction of mice

L Li, Z Pei, R Wu, Y Zhang, Y Pang, H Hu, W Hu… - Ecotoxicology and …, 2023 - Elsevier
Epidemiological studies have established an association between chronic exposure to PM
2.5 and male infertility. However, the underlying mechanisms were not fully revealed. In this …

Site-specific Atg13 methylation-mediated autophagy regulates epithelial inflammation in PM2. 5-induced pulmonary fibrosis

J Ning, Z Pei, M Wang, H Hu, M Chen, Q Liu… - Journal of hazardous …, 2023 - Elsevier
Abstract Fine particulate matters (PM2. 5) increased the risk of pulmonary fibrosis. However,
the regulatory mechanisms of lung epithelium in pulmonary fibrosis remained elusive. Here …

The role of autophagy in idiopathic pulmonary fibrosis: from mechanisms to therapies

YL Yue, MY Zhang, JY Liu, LJ Fang… - … in Respiratory Disease, 2022 - journals.sagepub.com
Idiopathic pulmonary fibrosis (IPF) is an interstitial pulmonary disease with an extremely
poor prognosis. Autophagy is a fundamental intracellular process involved in maintaining …

MIR222HG attenuates macrophage M2 polarization and allergic inflammation in allergic rhinitis by targeting the miR146a-5p/TRAF6/NF-κB axis

S Wen, F Li, Y Tang, L Dong, Y He, Y Deng… - Frontiers in …, 2023 - frontiersin.org
Although M2 macrophages are involved in the orchestration of type 2 inflammation in
allergic diseases, the mechanisms underlying non-coding RNA (ncRNA)-mediated …