Chronic inflammation is a component of many disease conditions that affect a large group of
individuals worldwide. Chronic inflammation is characterized by persistent, low-grade …

Type 1 diabetes is a chronic disease caused by autoimmune destruction of pancreatic β
cells. Individuals with type 1 diabetes are reliant on insulin for survival. Despite enhanced …

Transplantation of allogeneic pancreatic donor islets has successfully been performed in
selected patients with difficult-to-control insulin-dependent diabetes and impaired …

Impaired chronic viral and tumor clearance has been attributed to CD8+ T cell exhaustion, a
differentiation state in which T cells have reduced and altered effector function that can be …

Type 1 diabetes affects millions of people globally and requires careful management to
avoid serious long-term complications, including heart and kidney disease, stroke, and loss …

Obesity is characterized by an increase in body weight associated with an exaggerated
enlargement of the adipose tissue. Obesity has serious negative effects because it is …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

Mesenchymal stromal cells (MSC) are attractive tools for cell-based therapy, yet the
mechanisms underlying their migration and survival post-transplantation are unclear …

The balance between inflammatory and anti-inflammatory immune responses is maintained
through immunoregulatory cell populations and immunosuppressive cytokines. Interleukin …

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that mediates
the toxicities of several environmental pollutants. Decades of research have been carried …