[HTML][HTML] 3D cell culture models as recapitulators of the tumor microenvironment for the screening of anti-cancer drugs
Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …
alternatives for initial drug screening to increase drug development efficiency. In addition to …
Modeling physiological events in 2D vs. 3D cell culture
Cell culture has become an indispensable tool to help uncover fundamental biophysical and
biomolecular mechanisms by which cells assemble into tissues and organs, how these …
biomolecular mechanisms by which cells assemble into tissues and organs, how these …
Three-dimensional culture systems in cancer research: Focus on tumor spheroid model
S Nath, GR Devi - Pharmacology & therapeutics, 2016 - Elsevier
Cancer cells propagated in three-dimensional (3D) culture systems exhibit physiologically
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …
relevant cell–cell and cell–matrix interactions, gene expression and signaling pathway …
[HTML][HTML] Cell viability assays
This chapter is an introductory overview of the most commonly used assay methods to
estimate the number of viable cells in multi-well plates. This chapter describes assays where …
estimate the number of viable cells in multi-well plates. This chapter describes assays where …
Emerging tumor-on-chips with electrochemical biosensors
Cancer, one of the most dangerous diseases with a high mortality rate, has attracted much
attention and interest. Advances in tissue engineering and microfluidics have led to the …
attention and interest. Advances in tissue engineering and microfluidics have led to the …
Leishmaniasis drug discovery: recent progress and challenges in assay development
Highlights•Leishmaniasis remains a neglected tropical disease, with a high unmet medical
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …
need.•Therapeutic efficacy varies depending on the species of Leishmania parasite.•Leads …
Mimicking tumor microenvironment by 3D bioprinting: 3D cancer modeling
The tumor microenvironment (TME) typically comprises cancer cells, tumor vasculature,
stromal components like fibroblasts, and host immune cells that assemble to support …
stromal components like fibroblasts, and host immune cells that assemble to support …
Cell spheroids as a versatile research platform: formation mechanisms, high throughput production, characterization and applications
MC Decarli, R Amaral, DP Dos Santos, LB Tofani… - …, 2021 - iopscience.iop.org
Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …
[HTML][HTML] Cells grown in three-dimensional spheroids mirror in vivo metabolic response of epithelial cells
S Lagies, M Schlimpert, S Neumann, A Wäldin… - Communications …, 2020 - nature.com
Metabolism in cells adapts quickly to changes in nutrient availability and cellular
differentiation status, including growth conditions in cell culture settings. The last decade …
differentiation status, including growth conditions in cell culture settings. The last decade …
3D cell-based assays for drug screens: challenges in imaging, image analysis, and high-content analysis
TH Booij, LS Price, EHJ Danen - … Discovery: Advancing Life …, 2019 - journals.sagepub.com
The introduction of more relevant cell models in early preclinical drug discovery, combined
with high-content imaging and automated analysis, is expected to increase the quality of …
with high-content imaging and automated analysis, is expected to increase the quality of …