[HTML][HTML] Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases
Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …
[HTML][HTML] Key matrix remodeling enzymes: functions and targeting in cancer
Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …
activators and cathepsins, as well as non-proteolytic enzymatic partners, such as …
Low protease activity in B cell follicles promotes retention of intact antigens after immunization
The structural integrity of vaccine antigens is critical to the generation of protective antibody
responses, but the impact of protease activity on vaccination in vivo is poorly understood …
responses, but the impact of protease activity on vaccination in vivo is poorly understood …
[HTML][HTML] Cas13d knockdown of lung protease Ctsl prevents and treats SARS-CoV-2 infection
SARS-CoV-2 entry into cells requires specific host proteases; however, no successful in vivo
applications of host protease inhibitors have yet been reported for treatment of SARS-CoV-2 …
applications of host protease inhibitors have yet been reported for treatment of SARS-CoV-2 …
[HTML][HTML] Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
F Liew, C Efstathiou, S Fontanella, M Richardson… - Nature …, 2024 - nature.com
One in ten severe acute respiratory syndrome coronavirus 2 infections result in prolonged
symptoms termed long coronavirus disease (COVID), yet disease phenotypes and …
symptoms termed long coronavirus disease (COVID), yet disease phenotypes and …
[HTML][HTML] The role of lysosomal cathepsins in neurodegeneration: Mechanistic insights, diagnostic potential and therapeutic approaches
A Drobny, SP Huarcaya, J Dobert, A Kluge… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Lysosomes are ubiquitous organelles with a fundamental role in maintaining cellular
homeostasis by mediating degradation and recycling processes. Cathepsins are the most …
homeostasis by mediating degradation and recycling processes. Cathepsins are the most …
[HTML][HTML] The extracellular matrix: its composition, function, remodeling, and role in tumorigenesis
The extracellular matrix (ECM) is a ubiquitous member of the body and is key to the
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …
maintenance of tissue and organ integrity. Initially thought to be a bystander in many cellular …
[HTML][HTML] The key role of lysosomal protease cathepsins in viral infections
M Scarcella, D d'Angelo, M Ciampa, S Tafuri… - International journal of …, 2022 - mdpi.com
Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …
Pathophysiology and risk factors of peripartum cardiomyopathy
Peripartum cardiomyopathy (PPCM) is a potentially fatal form of idiopathic heart failure with
variable prevalence across different countries and ethnic groups. The cause of PPCM is …
variable prevalence across different countries and ethnic groups. The cause of PPCM is …
The Drosophila toll pathway in innate immunity: from the core pathway toward effector functions
S Valanne, L Vesala, MK Maasdorp… - The Journal of …, 2022 - journals.aai.org
The fruit fly Drosophila melanogaster Toll signaling pathway has an evolutionarily
conserved role in controlling immune responses. Whereas the microbial recognition …
conserved role in controlling immune responses. Whereas the microbial recognition …