Maintenance of mitochondrial health is essential for neuronal survival and relies upon
dynamic changes in the mitochondrial network and effective mitochondrial quality control …

Mucin-type-O-glycosylation on proteins is integrally involved in human health and disease
and is coordinated by an enzyme family of 20 N-acetylgalactosaminyltransferases (GalNAc …

Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …

The fruit fly Drosophila melanogaster Toll signaling pathway has an evolutionarily
conserved role in controlling immune responses. Whereas the microbial recognition …

Lung cancer, a major contributor to cancer-related fatalities worldwide, involves a complex
pathogenesis. Cathepsins, lysosomal cysteine proteases, play roles in various physiological …

Cathepsin H (CatH) is a lysosomal cysteine protease with a unique aminopeptidase activity
that is extensively expressed in the lung, pancreas, thymus, kidney, liver, skin, and brain …

Human cysteine cathepsins form a family of eleven proteases (B, C, F, H, K, L, O, S, V, W,
X/Z) that play important roles in a considerable number of biological and pathophysiological …

Cathepsin K (CatK) is a part of the family of cysteine proteases involved in many important
processes, including the degradation activity of collagen 1 and elastin in bone resorption …

Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress
and invasion of erythrocytes, development of functional liver merozoites (prophylactic …

The spike protein (S) of SARS-CoV-2 is responsible for viral attachment and entry, thus a
major factor for host susceptibility, tissue tropism, virulence and pathogenicity. The S is …