In the last few years, advancement in the analysis of the MHC class II (MHC-II) ligandome in
several mouse and human haplotypes has increased our understanding of the molecular …

Ovarian cancer is a highly lethal disease that affects women. Early diagnosis and treatment
of women with early-stage disease improve the probability of survival. Unfortunately, the …

Despite therapeutic interventions for glioblastoma (GBM), cancer stem cells (CSCs) drive
recurrence. The precise mechanisms underlying CSC resistance, namely inhibition of cell …

Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally
located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or …

As the primary phagocytic cells of the central nervous system, microglia exquisitely regulate
their lysosomal activity to facilitate brain development and homeostasis. However …

Lysosomes, since their discovery, have been primarily known for degrading cellular
macromolecules. However, in recent studies, they have begun to emerge as crucial …

Cathepsins were first described, as endolysosomal proteolytic enzymes in reference to the
organelles where they degrade the bulk of endogenous and exogenous substrates in a …

Artificial intelligence (AI)-based approaches can now use electrocardiograms (ECGs) to
provide expert-level performance in detecting heart abnormalities and diagnosing disease …

Macrophages are the first encounters of invading bacteria and are responsible for engulfing
and digesting pathogens through phagocytosis leading to initiation of the innate …

Introduction: We previously identified that Cathepsin V (CTSV) expression is associated with
poor prognosis in ER+ breast cancer, particularly within the Luminal A subtype. Examination …