The identification of x-ray crystal structure of cathepsin B (CTSB) in the early 90's enabled
researchers to embark on a journey to understand and demystify its multiple catalytic …

Proteases are the most abundant enzyme gene family in vertebrates and they execute
essential functions in all living organisms. Their main role is to hydrolase the peptide bond …

This review provides a synopsis of transcriptional responses pertaining to interactions
between plant viruses and the insect vectors that transmit them in diverse modes. In the …

The stimulation of autophagy or lysosomes has been considered therapeutic for
neurodegenerative disorders because the accumulation of misfolded proteins is commonly …

Since the spread of the deadly virus SARS-CoV-2 in late 2019, researchers have restlessly
sought to unravel how the virus enters the host cells. Some proteins on each side of the …

Impaired activities and abnormally enlarged structures of endolysosomes are frequently
observed in Alzheimer disease (AD) brains. However, little is known about whether and how …

Background: Age-related macular degeneration (AMD) is a leading cause of blindness in
the industrialised world and is projected to affect> 280 million people worldwide by 2040 …

The extracellular matrix (ECM) is a dynamic structure of molecules that can be divided into
six different categories and are collectively called the matrisome. The ECM plays pivotal …

The potential of designing irreversible alkyne-based inhibitors of cysteine cathepsins by
isoelectronic replacement in reversibly acting potent peptide nitriles was explored. The …

The three mammalian TET dioxygenases oxidize the methyl group of 5-methylcytosine in
DNA, and the oxidized methylcytosines are essential intermediates in all known pathways of …