[HTML][HTML] Narciclasine suppresses oral cancer metastasis by modulating cathepsin B and extracellular signal–related kinase pathways

MK Shieu, HY Ho, CC Lin, YS Lo, YC Chuang… - Biomedicine & …, 2023 - Elsevier
Oral cancer is a malignancy with unfavorable prognosis due to its high rates of recurrence
and lymph node metastasis. Narciclasine is extracted from Narcissus species …

[HTML][HTML] Receptors and cofactors that contribute to SARS-CoV-2 entry: can skin be an alternative route of entry?

M Barthe, L Hertereau, N Lamghari… - International Journal of …, 2023 - mdpi.com
To prevent the spread of SARS-CoV-2, all routes of entry of the virus into the host must be
mapped. The skin is in contact with the external environment and thus may be an alternative …

[HTML][HTML] Spatial transcriptomics reveals alterations in perivascular macrophage lipid metabolism in the onset of Wooden Breast myopathy in broiler chickens

Z Wang, P Khondowe, E Brannick, B Abasht - Scientific Reports, 2024 - nature.com
This study aims to use spatial transcriptomics to characterize the cell-type-specific
expression profile associated with the microscopic features observed in Wooden Breast …

[HTML][HTML] Niclosamide causes lysosome-dependent cell death in endometrial cancer cells and tumors.

R Rai, DK Dey, DM Benbrook, V Chandra - Biomedicine & …, 2023 - Elsevier
Endometrial cancer is the most common female cancer showing continuous rise in its
incidence and mortality rate. Despite the extensive research efforts in cancer therapeutics …

[HTML][HTML] Ursolic acid impairs cellular lipid homeostasis and lysosomal membrane integrity in breast carcinoma cells

DL Fogde, CPR Xavier, K Balnytė, LKK Holland… - Cells, 2022 - mdpi.com
Cancer is one of the leading causes of death worldwide, thus the search for new cancer
therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene …

[HTML][HTML] Untangling the extracellular matrix of idiopathic epiretinal membrane: a path winding among structure, interactomics and translational medicine

L Bianchi, A Altera, V Barone, D Bonente, T Bacci… - Cells, 2022 - mdpi.com
Idiopathic epiretinal membranes (iERMs) are fibrocellular sheets of tissue that develop at the
vitreoretinal interface. The iERMs consist of cells and an extracellular matrix (ECM) formed …

Design, synthesis and biological evaluation of a new series of arylidene indanones as small molecules for targeted therapy of non-small cell lung carcinoma and …

MD Altıntop, A Özdemir, HE Temel… - European Journal of …, 2022 - Elsevier
In an attempt to identify small molecules for targeted therapy of non-small cell lung
carcinoma (NSCLC) and prostate cancer (PCa), new arylidene indanones (1–10) were …

[HTML][HTML] The molecular mechanisms of systemic sclerosis-associated lung fibrosis

JE Mouawad, C Feghali-Bostwick - International journal of molecular …, 2023 - mdpi.com
Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune disorder that affects
the connective tissues and has the highest mortality rate among the rheumatic diseases …

[HTML][HTML] Translation inhibitors activate autophagy master regulators TFEB and TFE3

TT Dang, SH Back - International Journal of Molecular Sciences, 2021 - mdpi.com
The autophagy-lysosome pathway is a major protein degradation pathway stimulated by
multiple cellular stresses, including nutrient or growth factor deprivation, hypoxia, misfolded …

[HTML][HTML] Mechanisms applied by protein inhibitors to inhibit cysteine proteases

L Tušar, A Usenik, B Turk, D Turk - International Journal of Molecular …, 2021 - mdpi.com
Protein inhibitors of proteases are an important tool of nature to regulate and control
proteolysis in living organisms under physiological and pathological conditions. In this …