[HTML][HTML] Narciclasine suppresses oral cancer metastasis by modulating cathepsin B and extracellular signal–related kinase pathways
MK Shieu, HY Ho, CC Lin, YS Lo, YC Chuang… - Biomedicine & …, 2023 - Elsevier
Oral cancer is a malignancy with unfavorable prognosis due to its high rates of recurrence
and lymph node metastasis. Narciclasine is extracted from Narcissus species …
and lymph node metastasis. Narciclasine is extracted from Narcissus species …
[HTML][HTML] Receptors and cofactors that contribute to SARS-CoV-2 entry: can skin be an alternative route of entry?
M Barthe, L Hertereau, N Lamghari… - International Journal of …, 2023 - mdpi.com
To prevent the spread of SARS-CoV-2, all routes of entry of the virus into the host must be
mapped. The skin is in contact with the external environment and thus may be an alternative …
mapped. The skin is in contact with the external environment and thus may be an alternative …
[HTML][HTML] Spatial transcriptomics reveals alterations in perivascular macrophage lipid metabolism in the onset of Wooden Breast myopathy in broiler chickens
This study aims to use spatial transcriptomics to characterize the cell-type-specific
expression profile associated with the microscopic features observed in Wooden Breast …
expression profile associated with the microscopic features observed in Wooden Breast …
[HTML][HTML] Niclosamide causes lysosome-dependent cell death in endometrial cancer cells and tumors.
Endometrial cancer is the most common female cancer showing continuous rise in its
incidence and mortality rate. Despite the extensive research efforts in cancer therapeutics …
incidence and mortality rate. Despite the extensive research efforts in cancer therapeutics …
[HTML][HTML] Ursolic acid impairs cellular lipid homeostasis and lysosomal membrane integrity in breast carcinoma cells
DL Fogde, CPR Xavier, K Balnytė, LKK Holland… - Cells, 2022 - mdpi.com
Cancer is one of the leading causes of death worldwide, thus the search for new cancer
therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene …
therapies is of utmost importance. Ursolic acid is a naturally occurring pentacyclic triterpene …
[HTML][HTML] Untangling the extracellular matrix of idiopathic epiretinal membrane: a path winding among structure, interactomics and translational medicine
Idiopathic epiretinal membranes (iERMs) are fibrocellular sheets of tissue that develop at the
vitreoretinal interface. The iERMs consist of cells and an extracellular matrix (ECM) formed …
vitreoretinal interface. The iERMs consist of cells and an extracellular matrix (ECM) formed …
Design, synthesis and biological evaluation of a new series of arylidene indanones as small molecules for targeted therapy of non-small cell lung carcinoma and …
MD Altıntop, A Özdemir, HE Temel… - European Journal of …, 2022 - Elsevier
In an attempt to identify small molecules for targeted therapy of non-small cell lung
carcinoma (NSCLC) and prostate cancer (PCa), new arylidene indanones (1–10) were …
carcinoma (NSCLC) and prostate cancer (PCa), new arylidene indanones (1–10) were …
[HTML][HTML] The molecular mechanisms of systemic sclerosis-associated lung fibrosis
JE Mouawad, C Feghali-Bostwick - International journal of molecular …, 2023 - mdpi.com
Systemic sclerosis (SSc), also known as scleroderma, is an autoimmune disorder that affects
the connective tissues and has the highest mortality rate among the rheumatic diseases …
the connective tissues and has the highest mortality rate among the rheumatic diseases …
[HTML][HTML] Translation inhibitors activate autophagy master regulators TFEB and TFE3
TT Dang, SH Back - International Journal of Molecular Sciences, 2021 - mdpi.com
The autophagy-lysosome pathway is a major protein degradation pathway stimulated by
multiple cellular stresses, including nutrient or growth factor deprivation, hypoxia, misfolded …
multiple cellular stresses, including nutrient or growth factor deprivation, hypoxia, misfolded …
[HTML][HTML] Mechanisms applied by protein inhibitors to inhibit cysteine proteases
Protein inhibitors of proteases are an important tool of nature to regulate and control
proteolysis in living organisms under physiological and pathological conditions. In this …
proteolysis in living organisms under physiological and pathological conditions. In this …