The neuronal ceroid lipofuscinoses (NCLs), also referred to as Batten disease, are a family
of neurodegenerative diseases that affect all age groups and ethnicities around the globe. At …

Cathepsin B is a lysosomal cysteine protease that plays an important role in cancer,
atherosclerosis, and other inflammatory diseases. The suppression of cathepsin B can …

Mitochondria support the energetic demands of the cells. Autophagic turnover of
mitochondria serves as a critical pathway for mitochondrial homeostasis. It is unclear how …

The severity of the SARS-CoV-2 pandemic and the recurring (re) emergence of viruses
prompted the development of new therapeutic approaches that target viral and host factors …

Lipid-related disorders, which primarily affect metabolic tissues, including adipose tissue
and the liver are associated with alterations in lysosome homeostasis. Obesity is one of the …

Neuropeptides mediate cell–cell signaling in the nervous and endocrine systems. The
neuropeptidome is the spectrum of peptides generated from precursors by proteolysis within …

Technogenic metals like cadmium (Cd) are discharged into the environment posing
significant ecological risks to wildlife and contributing to a decline in biodiversity. Recent …

Many clinically used antiviral drugs are nucleoside or nucleotide analog drugs, which have
a unique mechanism of action that requires intracellular phosphorylation. This dependence …

Feline infectious peritonitis (FIP) is a disease of domestic cats caused by the genetic variant
of the feline coronavirus (FCoV) and feline infectious peritonitis virus (FIPV), currently …

Helminth parasites secrete several types of biomolecules to ensure their entry and survival
in their hosts. The proteins secreted to the extracellular environment participate in the …