Objectives Lung fibrosis is the leading cause of death in SSc, with no cure currently
available. Antifibrotic Endostatin (ES) production does not reach therapeutic levels in SSc …

Cysteine cathepsins play an important role in tumor development and metastasis. The
expression of these enzymes is often increased in many types of tumor cells. Cysteine …

Simple Summary Lysosomes are a critical component of the inner membrane system and
are involved in various cellular biological processes, including macromolecular degradation …

It is widely anticipated that a reduction of brain levels of the cellular prion protein (PrPC) can
prolong survival in a group of neurodegenerative diseases known as prion diseases. To …

Ebola virus (EBOV) causes a hemorrhagic fever with fatality rates up to 90%. The EBOV
entry process is complex and incompletely understood. Following attachment to host cells …

From a pathogenetic point of view, heart failure (HF) is characterized by the activation of
several neurohumoral pathways with a role in maintaining the cardiac output and the …

Mucopolysaccharidosis (MPS) consists of a group of inherited lysosomal storage disorders
that are caused by a defect of certain enzymes that participate in the metabolism of …

The differential enzymatic activity in the endo/lysosomes of particular cells could trigger
targeted endosomal escape functions, enabling selective intracellular protein delivery …

BACKGROUND: Microvascular complications are the major outcome of type 2 diabetes
progression, and the underlying mechanism remains to be determined. METHODS: High …

A typical neuron consists of a soma, a single axon with numerous nerve terminals, and
multiple dendritic trunks with numerous branches. Each of the 100 billion neurons in the …