Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Our sense of touch emerges from an array of mechanosensory structures residing within the
fabric of our skin. These tactile end organ structures convert innocuous forces acting on the …

Nociceptors are specialized sensory neurons that detect damaging or potentially damaging
stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These …

Although complex inflammatory-like alterations are observed around the amyloid plaques of
Alzheimer's disease (AD), little is known about the molecular changes and cellular …

Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …

Itch triggers scratching, a behavioural defence mechanism that aids in the removal of
harmful irritants and parasites. Chemical itch is triggered by many endogenous and …

Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory
peripheral nervous systems,,,–. Whether the neo-innervation of tumours by pain-initiating …

Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

In recent years, single-cell RNA sequencing (scRNA-seq) has emerged as a powerful
technique for investigating cellular heterogeneity and structure. However, analyzing scRNA …

Here we present a compendium of single-cell transcriptomic data from the model organism
Mus musculus that comprises more than 100,000 cells from 20 organs and tissues. These …