Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …

Antitumor suicide gene therapy is one of the emerging strategies against cancer. It consists
of the introduction into cancer cells of a gene capable of converting a nontoxic prodrug into a …

During multistage carcinogenesis, multiple genetic changes progressively accumulate in a
cell until it acquires a complete set of altered genes necessary for malignant phenotype …

Connexins (cx), structural components of gap junction, are believed to play a role in the
regulation of cell proliferation and suppression of the neoplastic phenotype. We used human …

F10 and BL6 sublines of B16 mouse melanoma cells are metastatic after intravenous
injection, but only BL6 cells are metastatic after subcutaneous injection. We found that …

In addition to the immediate microenvironment, long-range signaling may be an important
component of cancer. Molecular-genetic analyses have implicated gap junctions—key …

The aim of this study was to test whether radiation-induced bystander effects are involved in
the response of multicellular systems to targeted irradiation. A primary explant technique …

Gap junction-mediated communication is required for normal cellular growth and
differentiation. As cancer is thought to be a manifestation of the breakdown of cell-cell …

To evaluate the regulation of connexin expression by fluid pressure, we have studied the
effects of elevated transmural urine pressure on Connexin43 (Cx43) and Cx26. We chose to …

BACKGROUND, AIMS: Genomewide expression profiling has identified a number of genes
expressed at higher levels in colorectal cancer (CRC) than in normal tissues. Our objectives …