[HTML][HTML] Dysregulation of metabolic pathways in pulmonary fibrosis

R Rajesh, R Atallah, T Bärnthaler - Pharmacology & Therapeutics, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disorder of unknown origin and
the most common interstitial lung disease. It progresses with the recruitment of fibroblasts …

Metabolic reprogramming of pulmonary fibrosis

J Li, X Zhai, X Sun, S Cao, Q Yuan… - Frontiers in …, 2022 - frontiersin.org
Pulmonary fibrosis is a progressive and intractable lung disease with fibrotic features that
affects alveoli elasticity, which leading to higher rates of hospitalization and mortality …

17β-hydroxysteroid dehydrogenases in the progression of nonalcoholic fatty liver disease

MX Wang, ZG Peng - Pharmacology & Therapeutics, 2023 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic and a major
public health problem, with a prevalence of approximately 25%. The pathogenesis of …

[HTML][HTML] Mechanical stress regulates the mechanotransduction and metabolism of cardiac fibroblasts in fibrotic cardiac diseases

G Tian, T Ren - European Journal of Cell Biology, 2023 - Elsevier
Fibrotic cardiac diseases are characterized by myocardial fibrosis that results in maladaptive
cardiac remodeling. Cardiac fibroblasts (CFs) are the main cell type responsible for fibrosis …

[HTML][HTML] Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism

G Tian, J Zhou, Y Quan, Q Kong, J Li, Y Xin, W Wu… - Redox Biology, 2023 - Elsevier
Cardiac fibrosis is characterized by the excessive deposition of extracellular matrix in the
myocardium with cardiac fibroblast activation, leading to chronic cardiac remodeling and …

Roles of lipid metabolism and its regulatory mechanism in idiopathic pulmonary fibrosis: A review

Y Tian, C Duan, J Feng, J Liao, Y Yang… - The International Journal of …, 2023 - Elsevier
Idiopathic pulmonary fibrosis is a progressive lung disease of unknown etiology
characterized by distorted distal lung architecture, inflammation, and fibrosis. Several lung …

[HTML][HTML] ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis

L Wang, H Yuan, W Li, P Yan, M Zhao, Z Li… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease of
unknown etiology. The emerging evidence demonstrates that metabolic homeostatic …

Metabolic fingerprinting of systemic sclerosis: a systematic review

V Morales-González, D Galeano-Sánchez… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Systemic sclerosis (SSc) is a chronic autoimmune disease, marked by an
unpredictable course, high morbidity, and increased mortality risk that occurs especially in …

A mitochondrial-targeted near-infrared fluorescent probe for visualizing the fluctuation of hypochlorite acid in idiopathic pulmonary fibrosis mice

S Li, P Wang, Y Liu, K Yang, R Zhong, D Cheng… - Analytica Chimica …, 2023 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic inflammatory disease destroying lungs
irreversibly with high mortality rates. There are challenges in diagnosing IPF and treating it …

Immunometabolism changes in fibrosis: from mechanisms to therapeutic strategies

L Feng, X Chen, Y Huang, X Zhang… - Frontiers in …, 2023 - frontiersin.org
Immune cells are essential for initiating and developing the fibrotic process by releasing
cytokines and growth factors that activate fibroblasts and promote extracellular matrix …