How DNA is organized in three dimensions inside the cell nucleus and how this affects the
ways in which cells access, read and interpret genetic information are among the longest …

Mammalian genomes encode genetic information in their linear sequence, but appropriate
expression of their genes requires chromosomes to fold into complex three-dimensional …

A new level of chromosome organization, topologically associating domains (TADs), was
recently uncovered by chromosome conformation capture (3C) techniques. To explore TAD …

Although important for gene regulation, most studies of genome organization use either
fluorescence in situ hybridization (FISH) or chromosome conformation capture (3C) …

Conformation capture technologies (eg, Hi-C) chart physical interactions between chromatin
regions on a genome-wide scale. However, the structural variability of the genome between …

Background Long-range interactions between regulatory DNA elements such as enhancers,
insulators and promoters play an important role in regulating transcription. As chromatin …

DNA-binding proteins are central regulators of chromosome organization; however, in
genome-reduced bacteria their diversity is largely diminished. Whether the chromosomes of …

Chromosomes are large polymer molecules composed of nucleotides. In some species,
such as humans, this polymer can sum up to meters long and still be properly folded within …

Chromosome structure is a crucial regulatory factor for a wide range of nuclear processes.
Chromosome conformation capture (3C)-based experiments combined with computational …

Highlights•Integrative modeling needs standards and tools for assessing models and input
data.•Model uncertainty originates from sparse, noisy, ambiguous, or incoherent data.•Model …