The meninges are the fibrous covering of the central nervous system (CNS) which contain
vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia). The dural …

Leptomeningeal metastasis is an uncommon and typically late complication of cancer with a
poor prognosis and limited treatment options. Diagnosis is often challenging, with …

We molecularly dissected leptomeningeal metastasis, or spread of cancer to the
cerebrospinal fluid (CSF), which is a frequent and fatal condition mediated by unknown …

Leptomeningeal metastasis (LM) results from metastatic spread of cancer to the
leptomeninges, giving rise to central nervous system dysfunction. Breast cancer, lung …

Background: Diagnosis of leptomeningeal metastasis (LM) has become increasingly
frequent. The diagnostic gold standard has been CSF cytology, but MRI is now used …

An increasing fraction of patients with metastatic cancer develop leptomeningeal
dissemination of disease (LMD), and survival is dismal,–. We conducted a single-arm, phase …

Leptomeningeal metastasis occurs in~ 5% of all patients with cancer and is the third most
common metastatic complication of the central nervous system. Staging of leptomeningeal …

Background Diagnosis of leptomeningeal metastasis (LM) has become increasingly
common because of enhanced detection via routine use of magnetic resonance imaging …

Purpose To date, response criteria and optimal methods for assessment of outcome have
not been standardized in patients with leptomeningeal metastasis (LM). Methods A …

BACKGROUND: We analyzed the patterns of treatment and clinical outcomes of
leptomeningeal metastasis (LM) in patients with non-small cell lung cancer (NSCLC) in the …