The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by
orchestrating a wide variety of cellular responses, including damaged cell apoptosis …

Chemoresistance has been a significant problem affecting the efficacy of drugs targeting
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …

Glioblastoma multiforme is the most common aggressive adult primary tumour of the central
nervous system. Treatment includes surgery, radiotherapy and adjuvant temozolomide …

The DNA repair enzyme O 6-methylguanine-DNA methyltransferase (MGMT) antagonizes
the genotoxic effects of alkylating agents. MGMT promoter methylation is the key mechanism …

Glioblastoma is the most common primary malignant brain tumor. Although current standard
therapy extends median survival to~ 15 months, most patients do not have a sustained …

Alkylating agents have been used since the 60ties in brain cancer chemotherapy. Their
target is the DNA and, although the DNA of normal and cancer cells is damaged …

Background: Epigenetic silencing of O 6-methylguanine-DNA-methyltransferase (MGMT) by
promoter methylation is associated with improved survival in glioblastomas treated with …

O6-Methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the pre-
mutagenic, pre-carcinogenic and pre-toxic DNA damage O6-methylguanine. It also repairs …

DNA repair is the first barrier in the defense against genotoxic stress. In recent years,
mechanisms that recognize DNA damage and activate DNA repair functions through …

Glioblastoma multiforme (GBM) is a highly lethal and aggressive tumor of the brain that
carries a poor prognosis. Temozolomide (TMZ) has been widely used as a first-line …