[HTML][HTML] The mechanisms for pattern completion and pattern separation in the hippocampus

ET Rolls - Frontiers in systems neuroscience, 2013 - frontiersin.org
The mechanisms for pattern completion and pattern separation are described in the context
of a theory of hippocampal function in which the hippocampal CA3 system operates as a …

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

W Deng, JB Aimone, FH Gage - Nature reviews neuroscience, 2010 - nature.com
The integration of adult-born neurons into the circuitry of the adult hippocampus suggests an
important role for adult hippocampal neurogenesis in learning and memory, but its specific …

[HTML][HTML] Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion

T Nakashiba, JD Cushman, KA Pelkey, S Renaudineau… - Cell, 2012 - cell.com
Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate
gyrus, are highly active during the first few weeks after functional integration into the …

Hippocampal oxytocin receptors are necessary for discrimination of social stimuli

T Raam, KM McAvoy, A Besnard, AH Veenema… - Nature …, 2017 - nature.com
Oxytocin receptor (Oxtr) signaling in neural circuits mediating discrimination of social stimuli
and affiliation or avoidance behavior is thought to guide social recognition. Remarkably, the …

[PDF][PDF] CA3 retrieves coherent representations from degraded input: direct evidence for CA3 pattern completion and dentate gyrus pattern separation

JP Neunuebel, JJ Knierim - Neuron, 2014 - cell.com
Theories of associative memory suggest that successful memory storage and recall depend
on a balance between two complementary processes: pattern separation (to minimize …

Hippocampal replay in the awake state: a potential substrate for memory consolidation and retrieval

MF Carr, SP Jadhav, LM Frank - Nature neuroscience, 2011 - nature.com
The hippocampus is required for the encoding, consolidation and retrieval of event
memories. Although the neural mechanisms that underlie these processes are only partially …

[PDF][PDF] A multiplexed, heterogeneous, and adaptive code for navigation in medial entorhinal cortex

K Hardcastle, N Maheswaranathan, S Ganguli… - Neuron, 2017 - cell.com
Medial entorhinal grid cells display strikingly symmetric spatial firing patterns. The clarity of
these patterns motivated the use of specific activity pattern shapes to classify entorhinal cell …

Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders

MA Kheirbek, KC Klemenhagen, A Sahay… - Nature neuroscience, 2012 - nature.com
Although an influence of adult neurogenesis in mediating some of the effects of
antidepressants has received considerable attention in recent years, much less is known …

[PDF][PDF] Re-evaluating circuit mechanisms underlying pattern separation

NA Cayco-Gajic, RA Silver - Neuron, 2019 - cell.com
When animals interact with complex environments, their neural circuits must separate
overlapping patterns of activity that represent sensory and motor information. Pattern …

A computational theory of hippocampal function, and tests of the theory: new developments

RP Kesner, ET Rolls - Neuroscience & Biobehavioral Reviews, 2015 - Elsevier
The aims of the paper are to update Rolls' quantitative computational theory of hippocampal
function and the predictions it makes about the different subregions (dentate gyrus, CA3 and …