Optical genome mapping (OGM) is a new genome-wide technology that can reveal both
structural genomic variations (SVs) and copy number variations (CNVs) in a single assay …

Cytogenetics has long represented a critical component in the clinical evaluation of
hematologic malignancies. Chromosome banding studies provide a simultaneous snapshot …

Optical genome mapping (OGM) is a technology that is rapidly being adopted in clinical
genetics laboratories for its ability to detect structural variation (eg, translocations …

Simple Summary DUX4-rearrangement (DUX4r) is a recently discovered recurrent genomic
lesion reported in 4–7% of childhood B cell acute lymphoblastic leukaemia (B-ALL) cases …

Acute lymphoblastic leukemia (B‐ALL) with intrachromosomal amplification of chromosome
21 (iAMP21‐ALL) represents a recurrent high‐risk cytogenetic abnormality and accurate …

While PAX5 is an important tumor suppressor gene in B‐cell acute lymphoblastic leukemia
(B‐ALL), it is also involved in oncogenic translocations coding for diverse PAX5 fusion …

Summary JAK2 rearrangement (JAK2-R) in acute lymphoblastic leukemia (ALL) is rare and
often categorized as B-ALL with BCR:: ABL1–like features based on the World Health …

Cytogenomic analyses of acquired clonal chromosomal abnormalities in neoplastic blood,
bone marrow, and/or lymph nodes are instrumental in the clinical management of patients …

Philadelphia chromosome-like B-lymphoblastic leukemia (Ph-like ALL) describes a group of
genetically heterogeneous, Ph-negative entities with high relapse rates and poor …

Sustained remission after ruxolitinib and chimeric antigen receptor T-cell therapy bridged to a
second allogeneic hematopoietic stem cell transplantation for relapsed Philadelphia …