In vivo fluorescence recording techniques have produced landmark discoveries in
neuroscience, providing insight into how single cell and circuit-level computations mediate …

Fluorescent protein (FP)-based biosensors are genetically encoded tools that enable the
imaging of biological processes in the context of cells, tissues, or live animals. Though …

The ability to optically image cellular transmembrane voltages at millisecond-timescale
resolutions can offer unprecedented insight into the function of living brains in behaving …

Hybrid voltage indicators (HVIs) are chemogenetic sensors that combines the superior
photophysical properties of organic dyes and the genetic targetability of protein sensors to …

Here we report SUPPORT (statistically unbiased prediction utilizing spatiotemporal
information in imaging data), a self-supervised learning method for removing Poisson …

Electric pulses used in electroporation-based treatments have been shown to affect the
excitability of muscle and neuronal cells. However, understanding the interplay between …

Bioelectricity is the electrical activity that occurs within living cells and tissues. This activity is
critical for regulating homeostatic cellular function and communication, and disruptions of …

Dopamine (DA) is a critical neuromodulator involved in various brain functions. To
understand how DA regulates neural circuits and behaviors in the physiological and …

Voltage imaging with cellular specificity has been made possible by advances in genetically
encoded voltage indicators. However, the kilohertz rates required for voltage imaging lead to …

Genetically encoded fluorescent indicators are powerful tools for tracking cellular dynamic
processes. Engineering these indicators requires balancing screening dimensions with …