Role of zinc homeostasis in the pathogenesis of diabetes and obesity

A Fukunaka, Y Fujitani - International journal of molecular sciences, 2018 - mdpi.com
Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the
underlying molecular mechanisms remained unclear. The breakthrough discovery that the …

Properties and applications of flavonoid metal complexes

MM Kasprzak, A Erxleben, J Ochocki - Rsc Advances, 2015 - pubs.rsc.org
Flavonoids are widely occurring polyphenol compounds of plant origin with multiple
biological and chemical activities. Due to the presence of carbonyl and hydroxyl groups they …

[HTML][HTML] The enormity of the zinc deficiency problem and available solutions; an overview

ST Khan, A Malik, A Alwarthan, MR Shaik - Arabian Journal of Chemistry, 2022 - Elsevier
The societal cost of micronutrient deficiency (MND) or the “hidden hunger” is in millions of
dollars/year, reducing the GDP of some countries by as much as 11%. Zn is an important …

Mammalian zinc transporters: nutritional and physiologic regulation

LA Lichten, RJ Cousins - Annual review of nutrition, 2009 - annualreviews.org
Research advances defining how zinc is transported into and out of cells and organelles
have increased exponentially within the past five years. Research has progressed through …

Neurobiology of zinc and zinc-containing neurons

CJ Frederickson - International review of neurobiology, 1989 - Elsevier
Publisher Summary This chapter discusses separate pools of CNS zinc, which are, vesicular
zinc, free zinc, and protein-bound zinc. Vesicular zinc is the one which is sequestered in the …

The role of assembly in insulin's biosynthesis

G Dodson, D Steiner - Current opinion in structural biology, 1998 - Elsevier
Insulin is synthesised as a single-chain precursor, preproinsulin, that contains an N-terminal
signal sequence and a connecting peptide linking the A and B chains of the insulin …

Zinc and insulin in pancreatic beta-cells

YV Li - Endocrine, 2014 - Springer
Abstract Zinc (Zn 2+) is an essential element crucial for growth and development, and also
plays a role in cell signaling for cellular processes like cell division and apoptosis. In the …

Zinc and brain injury

DW Choi, JY Koh - Annual review of neuroscience, 1998 - annualreviews.org
▪ Abstract Zinc is an essential catalytic or structural element of many proteins, and a
signaling messenger that is released by neural activity at many central excitatory synapses …

Identification and cloning of a β-cell–specific zinc transporter, ZnT-8, localized into insulin secretory granules

F Chimienti, S Devergnas, A Favier, M Seve - Diabetes, 2004 - Am Diabetes Assoc
SLC30A8, a novel member of the zinc transporter (ZnT) family, was identified by searching
the human genomic and expressed sequence tag (EST) databases with the amino acid …

Solute carrier transporters as potential targets for the treatment of metabolic disease

T Schumann, J König, C Henke, DM Willmes… - Pharmacological …, 2020 - ASPET
The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …