Mechanisms controlling cellular and systemic iron homeostasis
In mammals, hundreds of proteins use iron in a multitude of cellular functions, including vital
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …
processes such as mitochondrial respiration, gene regulation and DNA synthesis or repair …
Genetic models of human and mouse dendritic cell development and function
Dendritic cells (DCs) develop in the bone marrow from haematopoietic progenitors that have
numerous shared characteristics between mice and humans. Human counterparts of mouse …
numerous shared characteristics between mice and humans. Human counterparts of mouse …
3D enhancer-promoter interactions and multi-connected hubs: Organizational principles and functional roles
CM Uyehara, E Apostolou - Cell reports, 2023 - cell.com
The spatiotemporal control of gene expression is dependent on the activity of cis-acting
regulatory sequences, called enhancers, which regulate target genes over variable genomic …
regulatory sequences, called enhancers, which regulate target genes over variable genomic …
Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch
Fetal hemoglobin (HbF, α 2 γ 2) level is genetically controlled and modifies severity of adult
hemoglobin (HbA, α 2 β 2) disorders, sickle cell disease, and β-thalassemia. Common …
hemoglobin (HbA, α 2 β 2) disorders, sickle cell disease, and β-thalassemia. Common …
Systematic mapping of functional enhancer–promoter connections with CRISPR interference
Gene expression in mammals is regulated by noncoding elements that can affect physiology
and disease, yet the functions and target genes of most noncoding elements remain …
and disease, yet the functions and target genes of most noncoding elements remain …
The 3D Genome Browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions
Here, we introduce the 3D Genome Browser, http://3dgenome. org, which allows users to
conveniently explore both their own and over 300 publicly available chromatin interaction …
conveniently explore both their own and over 300 publicly available chromatin interaction …
Nested epistasis enhancer networks for robust genome regulation
Mammalian genomes have multiple enhancers spanning an ultralong distance (>
megabases) to modulate important genes, but it is unclear how these enhancers coordinate …
megabases) to modulate important genes, but it is unclear how these enhancers coordinate …
Live-cell imaging reveals enhancer-dependent Sox2 transcription in the absence of enhancer proximity
Enhancers are important regulatory elements that can control gene activity across vast
genetic distances. However, the underlying nature of this regulation remains obscured …
genetic distances. However, the underlying nature of this regulation remains obscured …
Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing
Tissue-specific gene expression requires coordinated control of gene-proximal and-distal
cis-regulatory elements (CREs), yet functional analysis of gene-distal CREs such as …
cis-regulatory elements (CREs), yet functional analysis of gene-distal CREs such as …
Dictys: dynamic gene regulatory network dissects developmental continuum with single-cell multiomics
L Wang, N Trasanidis, T Wu, G Dong, M Hu… - Nature …, 2023 - nature.com
Gene regulatory networks (GRNs) are key determinants of cell function and identity and are
dynamically rewired during development and disease. Despite decades of advancement …
dynamically rewired during development and disease. Despite decades of advancement …