[HTML][HTML] Antimicrobial, antiproliferative activities and molecular docking of metabolites from Alternaria alternata

HT Khazaal, MT Khazaal, AS Abdel-Razek, AA Hamed… - AMB Express, 2023 - Springer
Endophytic fungi allied to plants have sparked substantial promise in discovering new
bioactive compounds. In this study, propagation of the endophytic fungus Alternaria …

Potential of African medicinal plants against Enterobacteria: Classification of plants antibacterial agents

V Kuete - Advances in Botanical Research, 2023 - Elsevier
In the present chapter, the synopsis of active botanicals and phytochemicals of the flora of
Africa against drug-sensitive and drug-resistant strains of bacteria of the Enterobacteriaceae …

Reviving antibiotics: efflux pump inhibitors that interact with AcrA, a membrane fusion protein of the AcrAB-TolC multidrug efflux pump

N Abdali, JM Parks, KM Haynes, JL Chaney… - ACS infectious …, 2017 - ACS Publications
Antibiotic resistance is a major threat to human welfare. Inhibitors of multidrug efflux pumps
(EPIs) are promising alternative therapeutics that could revive activities of antibiotics and …

[HTML][HTML] What approaches to thwart bacterial efflux pumps-mediated resistance?

AJ Seukep, HG Mbuntcha, V Kuete, Y Chu, E Fan… - Antibiotics, 2022 - mdpi.com
An effective response that combines prevention and treatment is still the most anticipated
solution to the increasing incidence of antimicrobial resistance (AMR). As the phenomenon …

[HTML][HTML] One-pot synthesis of pyrazolo [4, 3-d] thiazole derivatives containing α-aminophosphonate as potential Mur A inhibitors against MDR pathogens with …

A Ragab, SA Ibrahim, DS Aboul-Magd, MH Baren - RSC advances, 2023 - pubs.rsc.org
The present study involves the synthesis of a new series of α-aminophosphonate derivatives
in good yields with a simple workup via the Kabachnik–Fields reaction using lithium …

[HTML][HTML] The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: Urgent need for an improved new generation of EPIs

S Chetri - Frontiers in Microbiology, 2023 - frontiersin.org
Efflux pumps function as an advanced defense system against antimicrobials by reducing
the concentration of drugs inside the bacteria and extruding the substances outside. Various …

Chlorpromazine and amitriptyline are substrates and inhibitors of the AcrB multidrug efflux pump

EM Grimsey, C Fais, RL Marshall, V Ricci, ML Ciusa… - MBio, 2020 - Am Soc Microbiol
Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance.
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …

Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae

A Vieira Da Cruz, JC Jiménez-Castellanos… - EMBO Molecular …, 2024 - embopress.org
Antimicrobial resistance is a global problem, rendering conventional treatments less
effective and requiring innovative strategies to combat this growing threat. The tripartite …

Current advances in developing inhibitors of bacterial multidrug efflux pumps

HY Mahmood, S Jamshidi… - Current medicinal …, 2016 - ingentaconnect.com
Antimicrobial resistance represents a significant challenge to future healthcare provision. An
acronym ESKAPEE has been derived from the names of the organisms recognised as the …

[HTML][HTML] The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy

A Avakh, GD Grant, MJ Cheesman, T Kalkundri, S Hall - Antibiotics, 2023 - mdpi.com
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …