[HTML][HTML] Antimicrobial, antiproliferative activities and molecular docking of metabolites from Alternaria alternata
Endophytic fungi allied to plants have sparked substantial promise in discovering new
bioactive compounds. In this study, propagation of the endophytic fungus Alternaria …
bioactive compounds. In this study, propagation of the endophytic fungus Alternaria …
Potential of African medicinal plants against Enterobacteria: Classification of plants antibacterial agents
V Kuete - Advances in Botanical Research, 2023 - Elsevier
In the present chapter, the synopsis of active botanicals and phytochemicals of the flora of
Africa against drug-sensitive and drug-resistant strains of bacteria of the Enterobacteriaceae …
Africa against drug-sensitive and drug-resistant strains of bacteria of the Enterobacteriaceae …
Reviving antibiotics: efflux pump inhibitors that interact with AcrA, a membrane fusion protein of the AcrAB-TolC multidrug efflux pump
Antibiotic resistance is a major threat to human welfare. Inhibitors of multidrug efflux pumps
(EPIs) are promising alternative therapeutics that could revive activities of antibiotics and …
(EPIs) are promising alternative therapeutics that could revive activities of antibiotics and …
[HTML][HTML] What approaches to thwart bacterial efflux pumps-mediated resistance?
An effective response that combines prevention and treatment is still the most anticipated
solution to the increasing incidence of antimicrobial resistance (AMR). As the phenomenon …
solution to the increasing incidence of antimicrobial resistance (AMR). As the phenomenon …
[HTML][HTML] One-pot synthesis of pyrazolo [4, 3-d] thiazole derivatives containing α-aminophosphonate as potential Mur A inhibitors against MDR pathogens with …
The present study involves the synthesis of a new series of α-aminophosphonate derivatives
in good yields with a simple workup via the Kabachnik–Fields reaction using lithium …
in good yields with a simple workup via the Kabachnik–Fields reaction using lithium …
[HTML][HTML] The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: Urgent need for an improved new generation of EPIs
S Chetri - Frontiers in Microbiology, 2023 - frontiersin.org
Efflux pumps function as an advanced defense system against antimicrobials by reducing
the concentration of drugs inside the bacteria and extruding the substances outside. Various …
the concentration of drugs inside the bacteria and extruding the substances outside. Various …
Chlorpromazine and amitriptyline are substrates and inhibitors of the AcrB multidrug efflux pump
Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance.
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …
Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae
A Vieira Da Cruz, JC Jiménez-Castellanos… - EMBO Molecular …, 2024 - embopress.org
Antimicrobial resistance is a global problem, rendering conventional treatments less
effective and requiring innovative strategies to combat this growing threat. The tripartite …
effective and requiring innovative strategies to combat this growing threat. The tripartite …
Current advances in developing inhibitors of bacterial multidrug efflux pumps
HY Mahmood, S Jamshidi… - Current medicinal …, 2016 - ingentaconnect.com
Antimicrobial resistance represents a significant challenge to future healthcare provision. An
acronym ESKAPEE has been derived from the names of the organisms recognised as the …
acronym ESKAPEE has been derived from the names of the organisms recognised as the …
[HTML][HTML] The Art of War with Pseudomonas aeruginosa: Targeting Mex Efflux Pumps Directly to Strategically Enhance Antipseudomonal Drug Efficacy
Pseudomonas aeruginosa (P. aeruginosa) poses a grave clinical challenge due to its
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …
multidrug resistance (MDR) phenotype, leading to severe and life-threatening infections …