Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation

M Xue, VW Yong - The Lancet Neurology, 2020 - thelancet.com
Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …

Role of inflammatory processes in hemorrhagic stroke

SN Ohashi, JH DeLong, MG Kozberg, DJ Mazur-Hart… - Stroke, 2023 - Am Heart Assoc
Hemorrhagic stroke is the deadliest form of stroke and includes the subtypes of intracerebral
hemorrhage and subarachnoid hemorrhage. A common cause of hemorrhagic stroke in …

Autophagy regulates inflammation in intracerebral hemorrhage: Enemy or friend?

K Fu, W Xu, C Lenahan, Y Mo, J Wen… - Frontiers in Cellular …, 2023 - frontiersin.org
Intracerebral hemorrhage (ICH) is the second-largest stroke subtype and has a high
mortality and disability rate. Secondary brain injury (SBI) is delayed after ICH. The main …

Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia …

R Zhang, Y Dong, Y Liu, D Moezzi… - Stroke and Vascular …, 2023 - svn.bmj.com
Background Inflammation-exacerbated secondary brain injury and limited tissue
regeneration are barriers to favourable prognosis after intracerebral haemorrhage (ICH). As …

Central nervous system tissue regeneration after intracerebral hemorrhage: the next frontier

R Zhang, M Xue, VW Yong - Cells, 2021 - mdpi.com
Despite marked advances in surgical techniques and understanding of secondary brain
injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating …

Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage

T Imai, H Matsubara, H Hara - Journal of Cerebral Blood …, 2021 - journals.sagepub.com
Intracranial hemorrhage (ICH) is a devastating disease which induces high mortality and
poor outcomes including severe neurological dysfunctions. ICH pathology is divided into two …

Microglia phenotype and intracerebral hemorrhage: A Balance of Yin and Yang

R Bi, Z Fang, M You, Q He, B Hu - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Intracerebral hemorrhage (ICH) features extremely high rates of morbidity and mortality, with
no specific and effective therapy. And local inflammation caused by the over-activated …

Spatiotemporal cofilin signaling, microglial activation, neuroinflammation, and cognitive impairment following hemorrhagic brain injury

DA Almarghalani, X Sha, RE Mrak, ZA Shah - Cells, 2023 - mdpi.com
Intracerebral hemorrhage (ICH) is a significant health concern associated with high
mortality. Cofilin plays a crucial role in stress conditions, but its signaling following ICH in a …

Innate immune anti-inflammatory response in human spontaneous intracerebral hemorrhage

A Shtaya, LR Bridges, R Williams, S Trippier, L Zhang… - Stroke, 2021 - Am Heart Assoc
Background and Purpose: Spontaneous intracerebral hemorrhage (sICH) is a common form
of hemorrhagic stroke, with high mortality and morbidity. Pathophysiological mechanisms in …

Brain injury and repair after intracerebral hemorrhage: The role of microglia and brain-infiltrating macrophages

R Dasari, F Bonsack, S Sukumari-Ramesh - Neurochemistry international, 2021 - Elsevier
Intracerebral hemorrhage (ICH) is a major public health problem characterized by cerebral
bleeding. Despite recent advances in preclinical studies, there is no effective treatment for …