Neuroinflammation in intracerebral haemorrhage: immunotherapies with potential for translation
Intracerebral haemorrhage is inadequately controlled by current treatments, requiring new
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …
solutions to improve the prognosis. Following the primary injury, a proinflammatory cascade …
Role of inflammatory processes in hemorrhagic stroke
SN Ohashi, JH DeLong, MG Kozberg, DJ Mazur-Hart… - Stroke, 2023 - Am Heart Assoc
Hemorrhagic stroke is the deadliest form of stroke and includes the subtypes of intracerebral
hemorrhage and subarachnoid hemorrhage. A common cause of hemorrhagic stroke in …
hemorrhage and subarachnoid hemorrhage. A common cause of hemorrhagic stroke in …
Autophagy regulates inflammation in intracerebral hemorrhage: Enemy or friend?
K Fu, W Xu, C Lenahan, Y Mo, J Wen… - Frontiers in Cellular …, 2023 - frontiersin.org
Intracerebral hemorrhage (ICH) is the second-largest stroke subtype and has a high
mortality and disability rate. Secondary brain injury (SBI) is delayed after ICH. The main …
mortality and disability rate. Secondary brain injury (SBI) is delayed after ICH. The main …
Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia …
Background Inflammation-exacerbated secondary brain injury and limited tissue
regeneration are barriers to favourable prognosis after intracerebral haemorrhage (ICH). As …
regeneration are barriers to favourable prognosis after intracerebral haemorrhage (ICH). As …
Central nervous system tissue regeneration after intracerebral hemorrhage: the next frontier
Despite marked advances in surgical techniques and understanding of secondary brain
injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating …
injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating …
Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage
T Imai, H Matsubara, H Hara - Journal of Cerebral Blood …, 2021 - journals.sagepub.com
Intracranial hemorrhage (ICH) is a devastating disease which induces high mortality and
poor outcomes including severe neurological dysfunctions. ICH pathology is divided into two …
poor outcomes including severe neurological dysfunctions. ICH pathology is divided into two …
Microglia phenotype and intracerebral hemorrhage: A Balance of Yin and Yang
R Bi, Z Fang, M You, Q He, B Hu - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
Intracerebral hemorrhage (ICH) features extremely high rates of morbidity and mortality, with
no specific and effective therapy. And local inflammation caused by the over-activated …
no specific and effective therapy. And local inflammation caused by the over-activated …
Spatiotemporal cofilin signaling, microglial activation, neuroinflammation, and cognitive impairment following hemorrhagic brain injury
Intracerebral hemorrhage (ICH) is a significant health concern associated with high
mortality. Cofilin plays a crucial role in stress conditions, but its signaling following ICH in a …
mortality. Cofilin plays a crucial role in stress conditions, but its signaling following ICH in a …
Innate immune anti-inflammatory response in human spontaneous intracerebral hemorrhage
A Shtaya, LR Bridges, R Williams, S Trippier, L Zhang… - Stroke, 2021 - Am Heart Assoc
Background and Purpose: Spontaneous intracerebral hemorrhage (sICH) is a common form
of hemorrhagic stroke, with high mortality and morbidity. Pathophysiological mechanisms in …
of hemorrhagic stroke, with high mortality and morbidity. Pathophysiological mechanisms in …
Brain injury and repair after intracerebral hemorrhage: The role of microglia and brain-infiltrating macrophages
R Dasari, F Bonsack, S Sukumari-Ramesh - Neurochemistry international, 2021 - Elsevier
Intracerebral hemorrhage (ICH) is a major public health problem characterized by cerebral
bleeding. Despite recent advances in preclinical studies, there is no effective treatment for …
bleeding. Despite recent advances in preclinical studies, there is no effective treatment for …