Critical parameters in the quantitation of altered hepatic foci (AHF) developing during
multistage hepatocarcinogenesis in the rat include: 1) the enumeration of AHF induced by …

Enzymes of glutathione metabolism, particularly gamma-glutamyltransferase (GGT) and
glutathione S-transferase (GST), play a role in multistage hepatocarcinogenesis. The …

Natural compounds which elevate detoxification enzymes and/or reduce activating enzymes
could be considered as good candidates to protect against cancer. In this work, we studied …

Several models in rat liver have been developed to study multistage carcinogenesis,
including the Solt–Farber resistant hepatocyte model. In this model, initiation consists of …

Tamoxifen is a well-tolerated palliative and adjuvant treatment for human breast cancer and
requires continuous, long-term administration for optimal therapeutic effectiveness. A two …

Specific biochemical changes occurring during hepatocarcinogenesis have been sought by
many investigators. The development of multistage models for hepatocarcinogenesis in the …

Abstract An Initiation-Promotion Assay in Rat Liver as a Potential Complement to the 2-Year
Carcinogenesis Bioassay. DRAGAN, YP, RIZVI, T., XU, Y.-H., HULLY, JR, BAWA, N …

Altered hepatic foci (AHF) were analyzed by quantitative stereology on frozen serial sections
stained sequentially for γ-glutamyltranspeptidase (GGT), canalicular adenosine …

The identification of biological “markers” indicating distinctively different functions between
preneoplastic and neoplastic as compared with normal cells has been a subject of intensive …

With increased knowledge of the stages of initiation and promotion in the natural history of
neoplastic development and the multiple observations that such stages are likely to be …