Novel CAR T therapy is a ray of hope in the treatment of seriously ill AML patients

F Marofi, HS Rahman, ZMJ Al-Obaidi, AT Jalil… - Stem Cell Research & …, 2021 - Springer
Acute myeloid leukemia (AML) is a serious, life-threatening, and hardly curable
hematological malignancy that affects the myeloid cell progenies and challenges patients of …

Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges

RM Shallis, R Wang, A Davidoff, X Ma, AM Zeidan - Blood reviews, 2019 - Elsevier
Acute myeloid leukemia (AML) is a malignant disorder of the bone marrow which is
characterized by the clonal expansion and differentiation arrest of myeloid progenitor cells …

Acute myeloid leukaemia

NJ Short, ME Rytting, JE Cortes - The Lancet, 2018 - thelancet.com
For several decades, few substantial therapeutic advances have been made for patients
with acute myeloid leukaemia. However, since 2017 unprecedented growth has been seen …

Acute myeloid leukemia

H Döhner, DJ Weisdorf… - New England Journal of …, 2015 - Mass Medical Soc
Acute Myeloid Leukemia | NEJM Skip to main content NEJM Group Follow Us Facebook Twitter
Instagram YouTube LinkedIn Prepare to become a physician, build your knowledge, lead a …

Allogeneic hematopoietic cell transplantation for acute myeloid leukemia: time to move toward a minimal residual disease–based definition of complete remission?

D Araki, BL Wood, M Othus, JP Radich… - Journal of Clinical …, 2016 - ascopubs.org
Purpose Patients with acute myeloid leukemia (AML) who are in morphologic complete
remission are typically considered separately from patients with active disease (ie,≥ 5 …

Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia

DS Ritchie, PJ Neeson, A Khot, S Peinert, T Tai… - Molecular Therapy, 2013 - cell.com
In a phase I study of autologous chimeric antigen receptor (CAR) anti-LeY T-cell therapy of
acute myeloid leukemia (AML), we examined the safety and postinfusion persistence of …

The European LeukemiaNet AML Working Party consensus statement on allogeneic HSCT for patients with AML in remission: an integrated-risk adapted approach

JJ Cornelissen, A Gratwohl, RF Schlenk… - Nature reviews Clinical …, 2012 - nature.com
Allogeneic haematopoietic stem-cell transplantation (HSCT) is frequently applied as part of
the treatment in patients with acute myeloid leukaemia (AML) in their first or subsequent …

The cytokine network in acute myeloid leukemia (AML): A focus on pro-and anti-inflammatory mediators

S Binder, M Luciano, J Horejs-Hoeck - Cytokine & growth factor reviews, 2018 - Elsevier
Cytokines exert profound effects on the progression of hematopoietic malignancies such as
acute myeloid leukemia (AML). Critical roles of cytokines in the context of inflammation have …

DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies

AP Im, AR Sehgal, MP Carroll, BD Smith, A Tefferi… - Leukemia, 2014 - nature.com
The development of effective treatment strategies for most forms of acute myeloid leukemia
(AML) has languished for the past several decades. There are a number of reasons for this …

Pre-and post-transplant quantification of measurable ('minimal') residual disease via multiparameter flow cytometry in adult acute myeloid leukemia

Y Zhou, M Othus, D Araki, BL Wood, JP Radich… - Leukemia, 2016 - nature.com
Abstract Measurable ('minimal') residual disease (MRD) before or after hematopoietic cell
transplantation (HCT) identifies adults with AML at risk of poor outcomes. Here, we studied …