High rates of relapse to drug use during abstinence is a defining feature of drug addiction. In
abstinent drug users, drug relapse is often precipitated by acute exposure to the self …

Cue-induced methamphetamine seeking progressively increases after withdrawal
(incubation of methamphetamine craving), but the underlying mechanisms are largely …

Despite decades of research in the field of addiction, relapse rates for substance use
disorders remain high. Consequently, there has been growing focus on providing evidence …

Background The incubation of cue-induced drug craving in rodents provides a model of
persistent vulnerability to craving and relapse in human addicts. After prolonged withdrawal …

The interaction between social factors and alcohol addiction is complex, with potential for
both positive and negative contributions to drug use and abstinence. Positive social …

Background Based on rodent studies, group II metabotropic glutamate receptors (mGluR2
and mGluR3) were suggested as targets for addiction treatment. However, LY379268 and …

High relapse rate is a key feature of opioid addiction. In humans, abstinence is often
voluntary due to negative consequences of opioid seeking. To mimic this human condition …

Metabotropic glutamate (mGlu) receptors are expressed throughout the central nervous
system and act as important regulators of drug-induced neuroplasticity and behavior …

Abstract Psychostimulant Use Disorder (PUD) is a chronic relapsing disorder with high
motivation for drug abuse. In addition to developing PUD, the use of psychostimulants is a …

Rationale There are no FDA-approved treatments to facilitate recovery from cocaine use
disorder. Contingency management offers non-drug reinforcers to encourage abstinence …