Thymoquinone, as a novel therapeutic candidate of cancers

B Almajali, HAN Al-Jamal, WRW Taib, I Ismail… - Pharmaceuticals, 2021 - mdpi.com
To date, natural products are widely used as pharmaceutical agents for many human
diseases and cancers. One of the most popular natural products that have been studied for …

Thymoquinone, an active compound of Nigella sativa: role in prevention and treatment of cancer

SA Almatroodi, A Almatroudi, MA Alsahli… - Current …, 2020 - ingentaconnect.com
Background: Cancer is the leading cause of death worldwide and the current mode of
cancer treatment causes side effects on normal cells and are still the key challenges in its' …

Thymoquinone radiosensitizes human colorectal cancer cells in 2D and 3D culture models

S Al Bitar, F Ballout, A Monzer, M Kanso, N Saheb… - Cancers, 2022 - mdpi.com
Simple Summary Radiotherapy is a standard of care therapy that kills cancer cells but has
limited efficacy in targeting the resistant cancer stem cells (CSCs). The use of …

Plant-derived terpenoids: a promising tool in the fight against melanoma

P Kłos, D Chlubek - Cancers, 2022 - mdpi.com
Simple Summary Despite the numerous therapies, melanoma remains the deadliest of all
skin cancers; however, plant-derived terpenoids are defense molecules that have proven …

[HTML][HTML] Therapeutic potential of thymoquinone in combination therapy against cancer and cancer stem cells

Z Fatfat, M Fatfat, H Gali-Muhtasib - World journal of clinical …, 2021 - ncbi.nlm.nih.gov
The long-term success of standard anticancer monotherapeutic strategies has been
hampered by intolerable side effects, resistance to treatment and cancer relapse. These …

Recent findings on thymoquinone and its applications as a nanocarrier for the treatment of cancer and rheumatoid arthritis

RR Pal, V Rajpal, P Singh, SA Saraf - Pharmaceutics, 2021 - mdpi.com
Cancer causes a considerable amount of mortality in the world, while arthritis is an
immunological dysregulation with multifactorial pathogenesis including genetic and …

Thymoquinone induces apoptosis of human epidermoid carcinoma A431 cells through ROS-mediated suppression of STAT3

JE Park, DH Kim, E Ha, SM Choi, JS Choi… - Chemico-biological …, 2019 - Elsevier
Black seed (Nigella sativa) oil has been used in various dermatological applications, and its
major constituent, thymoquinone (TQ) has been shown to exhibit antiproliferative activity …

[HTML][HTML] Radiotherapy in preclinical models of brain metastases: a review and recommendations for future studies

W Shi, G Tanzhu, L Chen, J Ning, H Wang… - … Journal of Biological …, 2024 - ncbi.nlm.nih.gov
Brain metastases (BMs) frequently occur in primary tumors such as lung cancer, breast
cancer, and melanoma, and are associated with notably short natural survival. In addition to …

Response of skin-derived and metastatic human malignant melanoma cell lines to thymoquinone and thymoquinone-loaded liposomes

P Kłos, M Perużyńska, M Baśkiewicz-Hałasa… - Pharmaceutics, 2022 - mdpi.com
Thymoquinone has been proved to be effective against neoplasms, including skin cancer. Its
high lipophilicity, however, may limit its potential use as a drug. Melanoma remains the …

Anticancer and anti-metastatic role of thymoquinone: Regulation of oncogenic signaling cascades by thymoquinone

AA Farooqi, R Attar, B Xu - International Journal of Molecular Sciences, 2022 - mdpi.com
Cancer is a life-threatening and multifaceted disease. Pioneering research works in the past
three decades have mechanistically disentangled intertwined signaling networks which play …