Transmission-blocking vaccines: harnessing herd immunity for malaria elimination

PE Duffy - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction Transmission-blocking vaccines (TBV) prevent community spread of malaria by
targeting mosquito sexual stage parasites, a life-cycle bottleneck, and will be used in …

The PfAP2‐G2 transcription factor is a critical regulator of gametocyte maturation

S Singh, JM Santos, LM Orchard… - Molecular …, 2021 - Wiley Online Library
Differentiation from asexual blood stages to mature sexual gametocytes is required for the
transmission of malaria parasites. Here, we report that the ApiAP2 transcription factor, PfAP2 …

Plasmodium falciparum Development from Gametocyte to Oocyst: Insight from Functional Studies

DT Ouologuem, A Dara, A Kone, A Ouattara… - Microorganisms, 2023 - mdpi.com
Malaria elimination may never succeed without the implementation of transmission-blocking
strategies. The transmission of Plasmodium spp. parasites from the human host to the …

The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites

RA Campelo Morillo, X Tong, W Xie, S Abel… - Nature …, 2022 - nature.com
Transmission of Plasmodium falciparum and other malaria parasites requires their
differentiation from asexual blood stages into gametocytes, the non-replicative sexual stage …

Demographical, hematological and serological risk factors for Plasmodium falciparum gametocyte carriage in a high stable transmission zone in Cameroon

E Essangui, CE Eboumbou Moukoko, N Nguedia… - PLoS …, 2019 - journals.plos.org
Presence of mature gametocyte forms of malaria parasites in peripheral blood is a key
requirement for malaria transmission. Yet, studies conducted in most malaria transmission …

A novel DNA-binding protein regulates sexual differentiation in malaria parasites and is essential for transmission

RC Morillo, X Tong, W Xie, T Lenz, G Batugedara… - bioRxiv, 2020 - biorxiv.org
Transmission of Plasmodium falciparum and other malaria parasites requires their
differentiation from asexual blood stages into gametocytes, the non-replicative sexual stage …

[PDF][PDF] Immune-Based Interventions Against Infectious Disease-Impact of a Phase I Center for Biomedical Research Excellence in Translational Infectious Diseases …

AL Rothman, J Friedman, JD Kurtis - Rhode Island Medical Journal, 2021 - rimed.org
In 2011, faculty from the University of Rhode Island (URI)'s Institute for Immunology and
Informatics and Lifespan's Center for International Health Research collaborated to develop …

Applying next generation sequencing of genomes and transcriptomes to investigate the population structure and biology of Plasmodium species

S Hocking - 2020 - researchonline.lshtm.ac.uk
Plasmodium parasites, the causative agents of malaria, are responsible for a significant
burden of disease worldwide. Understanding populations and parasite biology is critical to …

Characterizing the Functional Role of the Transcriptional Regulator PfAP2-G2 in Plasmodium Falciparum Gametocytogenesis

S Singh - 2020 - search.proquest.com
Differentiation from asexual blood stages to sexual gametocytes is required for transmission
of malaria parasites from the human host to mosquitos, where sexual fertilization occurs to …