Contrary to the biosynthetic pathways of many terpenoids, which are well characterized and
elucidated, their transport inside subcellular compartments and the secretion of reaction …

Monoterpene indole alkaloids (MIAs) are endowed with high structural and spatial
complexity and characterized by diverse biological activities. Given this complexity‐activity …

Thousands of known alkaloids contain a nitrogen (N) heterocycle. While five-, six-and seven-
membered N-heterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and …

Neuroinflammation and oxidative stress play a crucial role in the pathogenesis of
neurodegenerative diseases, including Alzheimer's disease. The triggering receptor …

Ambelania duckei Markgr is a species of the Apocynaceae family, native to the Amazon
region that is unexplored from a nutritional point of view and studied in relation to its …

The first asymmetric total synthesis of the monoterpenoid indole alkaloid arboduridine has
been accomplished. The tricyclic A/B/D ring system was constructed by an enantioselective …

Monoterpene indole alkaloids (MIAs) are a class of natural products comprised of thousands
of structurally unique bioactive compounds with significant therapeutic values. Due to …

Bisindoles are structurally complex dimers and are intriguing targets for partial and total
synthesis. They exhibit stronger biological activity than their corresponding monomeric units …

The ability of the indole–imidazole hybrid ligands to coordinate with the Zn (II) ion and the
resulting structures of this new class of coordination compounds were analyzed in order to …

Density functional theory calculations were applied to predict the pathways of gold (I)-
catalyzed cycloisomerization of the indole substrates with 1, 6-enynes, which were …