Inherited retinal degeneration (RD) leads to the impairment or loss of vision in millions of
individuals worldwide, most frequently due to the loss of photoreceptor (PR) cells. Animal …

Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They
function as key regulators of embryonic development and a wide range of other …

Phospholipid scrambling (PLS) is a ubiquitous cellular mechanism involving the regulated
bidirectional transport of phospholipids down their concentration gradient between …

ABSTRACT The Ca2+‐activated Cl‒channel TMEM16A [anoctamin (ANO) 1] is homologous
to yeast Ist2 and has been shown to tether the cortical endoplasmic reticulum (ER) to the …

Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride
channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1 …

Primary cilia are immotile organelles known for their roles in development and cell signaling.
Defects in primary cilia result in a range of disorders named ciliopathies. Because this …

The primary cilium permits compartmentalization of specific signaling pathways, including
elements of the Hedgehog (Hh) pathway. Hh transcriptional activity is thought to be …

Since the discovery of TMEM16A (anoctamin 1, ANO1) as Ca 2+-activated Cl− channel, the
protein was found to serve different physiological functions, depending on the type of tissue …

Background and Purpose Natural flavonoids are ubiquitous in dietary plants and vegetables
and have been proposed to have antiviral, antioxidant, cardiovascular protective and …

Abstract Transmembrane member 16A (TMEM16A) encoded Ca 2+-activated Cl− channels
were found to be involved in tumorigenesis. Previous studies suggest the effect of TMEM16A …