Discrimination of RNA fiber structures using solid-state nanopores

P Tripathi, M Chandler, CM Maffeo, A Fallahi… - Nanoscale, 2022 - pubs.rsc.org
RNA fibers are a class of biomaterials that can be assembled using HIV-like kissing loop
interactions. Because of the programmability of molecular design and low …

Broccoli fluorets: split aptamers as a user-friendly fluorescent toolkit for dynamic RNA nanotechnology

M Chandler, T Lyalina, J Halman… - Therapeutic RNA …, 2021 - taylorfrancis.com
806RNA aptamers selected to bind fluorophores and activate their fluorescence offer a
simple and modular way to visualize native RNAs in cells. Split aptamers which are inactive …

Tuning properties of silver nanoclusters with RNA nanoring assemblies

L Yourston, L Rolband, C West, A Lushnikov, KA Afonin… - Nanoscale, 2020 - pubs.rsc.org
Combining atomically resolved DNA-templated silver nanoclusters (AgNCs) with nucleic
acid nanotechnology opens new exciting possibilities for engineering bioinorganic …

Simultaneous silencing of lysophosphatidylcholine acyltransferases 1-4 by nucleic acid nanoparticles (NANPs) improves radiation response of melanoma cells

RF Saito, MC Rangel, JR Halman, M Chandler… - … , Biology and Medicine, 2021 - Elsevier
Radiation induces the generation of platelet-activating factor receptor (PAF-R) ligands,
including PAF and oxidized phospholipids. Alternatively, PAF is also synthesized by the …

Gold nanoparticles as carriers for functional RNA nanostructures

A Graczyk, R Pawlowska, A Chworos - Bioconjugate Chemistry, 2021 - ACS Publications
Conjugates of gold nanoparticles and ribonucleic acid are particularly interesting for
biological applications to serve as therapeutics or biosensors. In this paper we present, for …

Challenges in optimizing RNA nanostructures for large-scale production and controlled therapeutic properties

M Chandler, M Panigaj, LA Rolband, KA Afonin - Nanomedicine, 2020 - Taylor & Francis
Nucleic acids have been utilized to construct an expansive collection of nanoarchitectures
varying in design, physicochemical properties, cellular processing and biomedical …

Multifunctional role of silica in pharmaceutical formulations

Y Gao, Y Zhang, Y Hong, F Wu, L Shen, Y Wang… - AAPS …, 2022 - Springer
Due to the high surface area, adjustable surface and pore structures, and excellent
biocompatibility, nano-and micro-sized silica have certainly attracted the attention of many …

Controlled organization of inorganic materials using biological molecules for activating therapeutic functionalities

M Chandler, B Minevich, B Roark, M Viard… - … applied materials & …, 2021 - ACS Publications
Precise control over the assembly of biocompatible three-dimensional (3D) nanostructures
would allow for programmed interactions within the cellular environment. Nucleic acids can …

Nucleic acid nanoparticles at a crossroads of vaccines and immunotherapies

MA Dobrovolskaia - Molecules, 2019 - mdpi.com
Vaccines and immunotherapies involve a variety of technologies and act through different
mechanisms to achieve a common goal, which is to optimize the immune response against …

Nanoparticle mediated silencing of tenascin C in hepatic stellate cells: effect on inflammatory gene expression and cell migration

JL Vivero-Escoto, H Vadarevu, R Juneja… - Journal of materials …, 2019 - pubs.rsc.org
Chronic liver dysfunction often begins with hepatic fibrosis. A pivotal event in the
progression of liver fibrosis and cirrhosis is hepatic stellate cell (HSC) activation and …