RNA is a functionally rich and diverse biomaterial responsible for regulating several cellular
processes. This functionality has been harnessed to build predominately small nanoscale …

Structural characterization of nucleic acid nanoparticles (NANPs) in solution is critical for
validation of correct assembly and for quantifying the size, shape, and flexibility of the …

Cold-chain storage can be challenging and expensive for the transportation and storage of
biologics, especially in low-resource settings. Nucleic acid nanoparticles (NANPs) are an …

In biological systems, conformational changes and allosteric modulation play pivotal roles in
regulating biological functions, such as the dynamic change of protein molecules, in …

Mesoporous silica nanoparticles (MSNs) are inorganic materials with a highly ordered
network of pores within a silicon oxide framework. This chapter focuses on describing the …

Nucleic acid nanoparticles (NANPs) are extensively investigated as diagnostic and
therapeutic tools. These innovative particles can be composed of RNA, DNA, and/or …

Nucleic acids carry out a diverse number of functions as carriers and regulators of gene
expression. By combining naturally occurring structural motifs with known base pairing rules …

This protocol assesses pro-inflammatory properties of nucleic acid nanoparticles (NANPs)
using a validated preclinical model, peripheral blood mononuclear cells (PBMCs), which are …

Viruses are genetically and phenotypically diverse infectious agents providing profound
selective pressure in the evolution of their host species with potential to significantly alter …

Nanomaterials have been extensively used for the delivery of nucleic acids. This is attributed
to the unique features of nanoparticles to carry genetic material with different …