The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …

Hematopoietic stem cell (HSC) transplantation can restore a new functional hematopoietic
system in recipients in cases where the system of the recipient is not functional or for …

INTRODUCTION The stem cell niche plays a crucial role in regulating key stem cell
properties, including self-renewal, differentiation, and cell fate change. Although stem cell …

Acute myelogenous leukemia (AML) is a heterogeneous disorder characterized by clonal
proliferation of stem cell-like blasts in bone marrow (BM); however, their unique cellular …

Hematopoietic stem cells (HSCs) play a key role in hematopoietic system that functions
mainly in homeostasis and immune response. HSCs transplantation has been applied for …

Notch and Wnt signaling are highly conserved intercellular communication pathways
involved in developmental processes, such as hematopoiesis. Even though data from …

Simple Summary B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric
cancer. Even though the cure rate actually exceeds 85%, the prognosis of …

The bone marrow (BM) niche is a specific physiological environment for hematopoietic and
non-hematopoietic stem cells (HSCs). Several signaling pathways (including Wnt/β-catenin) …

Tyrosine kinase inhibitor (TKI) treatment of chronic myeloid leukemia (CML) has limited
efficacy against leukemia stem cells (LSC) responsible for disease propagation, and most …

Considerable information has accumulated about components of BM that regulate the
survival, self-renewal, and differentiation of hematopoietic cells. In the present study, we …