It is now nearly 5 years since the last of the currently recognised 5-HT receptors was
identified in terms of its cDNA sequence. Over this period, much effort has been directed …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Parkinson's disease (PD) is most commonly a sporadic illness, and is characterized by
degeneration of substantia nigra dopamine (DA) neurons and abnormal cytoplasmic …

The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies
by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those …

Abstract The 5‐HT1A and 5‐HT1B receptors of serotonin play important roles as auto‐and
heteroreceptors controlling the release of serotonin itself and of other neurotransmitters …

Aggressive behavior in male and female mice occurs in conflicts with intruding rivals, most
often for the purpose of suppressing the reproductive success of the opponent. The …

Abstract Rationale Serotonin reuptake inhibitors (SSRIs) are effective in treating depression.
Given the existence of different families and subtypes of 5-HT receptors, multiple 5-HT …

The role of serotonin in major depressive disorder (MDD) is the focus of accumulating
clinical and preclinical research. The results of these studies reflect the complexity of …

The limbic system is composed of cortical as well as subcortical structures, which are
intimately interconnected. The resulting macrostructure is responsible for the generation and …

The serotonin system is strongly implicated in the pathophysiology and therapeutic
alleviation of stress-related disorders such as anxiety and depression. Serotonergic …