Thioesterase superfamily member 1 (Them1) is an acyl-CoA thioesterase that is highly
expressed in brown adipose tissue, where it functions to suppress energy expenditure …

Increased lipid metabolism in muscle is associated with insulin resistance and therefore,
many strategies have been employed to alter fatty acid metabolism and study the impact on …

Abscisic acid (ABA) receptors belong to the START domain superfamily, which
encompasses ligand‐binding proteins present in all kingdoms of life. START domain …

Hepatic insulin resistance in the setting of steatosis is attributable at least in part to the
accumulation of bioactive lipids that suppress insulin signaling. The mitochondria …

The immune system coordinates the response to cardiac injury and is known to control
regenerative and fibrotic scar outcomes in the heart and subsequent chronic low-grade …

Platelet activation in response to stimulation of the Protease Activated Receptor 4 (PAR4)
receptor differs by race. One factor that contributes to this difference is the expression level …

Pre-eclampsia is the most common pregnancy complication affecting 1 in 20 pregnancies,
characterized by high blood pressure and signs of organ damage, most often to the liver and …

The α isoform of the Class I phosphatidylinositol (PI) 3-kinases (PI3Ks), p110α (encoded by
PIK3CA), is an essential downstream mediator of insulin and other growth factors. When …

Liver and Biliary Tract Physiology/Pathophysiology: Phosphatidylcholine transfer protein/StarD2
promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis - PMC …

Metabolic diseases, including fatty liver disease, hyperglycemia, and obesity, result when
body systems responsible for managing allostasis (dynamic homeostasis across systems) …