Omega-3 fatty acid (omega-3 FA) consumption has long been associated with a lower
incidence of colon, breast and prostate cancers in many human populations. Human trials …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor
and is also intimately involved in tumorigenesis. FOXM1 stimulates cell proliferation and cell …

Vascular endothelial growth factor (VEGF) has a central role in breast cancer development
and progression, but the mechanisms that control its expression are poorly understood …

Although enhanced activation of the EGF receptor (EGFR) associates with the development
and progression of renal fibrosis, the mechanisms linking these observations are not …

The vast majority of diseases that cause catastrophic loss of vision do so as a result of ocular
neovascularization. During normal retinal vascular development, vascular endothelial cells …

Current development of targeted therapy in oncology is particularly active and concerns
principally two types of agents which are monoclonal antibodies (Mabs) and tyrosine kinase …

Chemoresistance contributes to cancer relapse and increased mortality in a variety of
cancer types, raising a pressing need to better understand the underlying mechanism …

The tyrosine kinase receptor, HER2 is a crucial prognostic marker and therapeutic target for
breast cancer; however, the downstream targets and biological effectors of HER2 remain …

Gefitinib (Iressa) is a specific and effective epidermal growth factor receptor inhibitor. An
understanding of the downstream cellular targets of gefitinib will allow the discovery of …

Purpose: The purpose of the present study was to evaluate the anti–epidermal growth factor
monoclonal antibody (mAb) cetuximab (IMC-C225) as a delivery agent for boron neutron …