The habenulo-interpeduncular system (HIPS) is now recognized as a critical circuit
modulating aversion, reward, and social behavior. There is evidence that dysfunction of this …

Nicotinic acetylcholine receptors (nAChRs) are the molecular target of nicotine. nAChRs in
the medial habenula (MHb) have recently been shown to play a role in nicotine …

The epithalamus, which is dorsal to the thalamus, consists of the habenula, pineal gland and
third ventricle choroid plexus and plays important roles in the stress response and sleep …

Accumulating evidence has reinforced that the habenular region of the vertebrate dorsal
forebrain is an essential integrating center, and a region strongly implicated in neurological …

The medial habenula-interpeduncular nucleus (MHb-IPN) pathway has recently been
implicated in the suppression of fear memory. A notable feature of this pathway is the …

The habenula (Hb) is a bilateral, evolutionarily conserved epithalamic structure connecting
forebrain and midbrain structures that has gained attention for its roles in depression …

Several series of experiments were designed to compare the effects of selective lesions of
the fimbria or of thalamic nuclei on three different tasks involving working memory in rats …

The medial and lateral habenulae are conserved throughout vertebrate evolution, and form
an integrated part in the forebrain control of behavior together with the basal ganglia, the …

Leucine-rich repeat-containing G-protein-coupled receptor 8 (LGR8; also classified as
relaxin family peptide 2 receptor; RXFP2) has been identified as a cognate receptor for the …

Abstract Background The interpeduncular nucleus (> 1840)(IPN) has been shown to
modulate the behavioral effects of nicotine withdrawal in male rodents. To date, the …