Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Lysosomes are catabolic organelles that govern numerous cellular processes, including
macromolecule degradation, nutrient signalling and ion homeostasis. Aberrant changes in …

Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and
immune systems after transplantation and can be used as a curative cell therapy for a variety …

Bone marrow haematopoietic stem cells (HSCs) are vital for lifelong maintenance of healthy
haematopoiesis. In inbred mice housed in gnotobiotic facilities, the top of the haematopoietic …

Metabolism has been studied mainly in cultured cells or at the level of whole tissues or
whole organisms in vivo. Consequently, our understanding of metabolic heterogeneity …

The mechanisms underlying metabolic adaptation of pancreatic ductal adenocarcinoma
(PDA) cells to pharmacologic inhibition of RAS–MAPK signaling are largely unknown. Using …

Hematopoietic stem cells (HSCs) regenerate blood cells throughout life. To preserve their
fitness, HSCs are particularly dependent on maintaining protein homeostasis (proteostasis) …

Stem cells perform many different functions, each of which requires specific metabolic
adaptations. Over the past decades, studies of pluripotent and tissue stem cells have …

Understanding human hematopoietic stem cell fate control is important for its improved
therapeutic manipulation. Asymmetric cell division, the asymmetric inheritance of factors …

The microphthalmia/transcription factor E (MiT/TFE) transcription factors (TFs; TFEB, TFE3,
MITF, and TFEC) play a central role in cellular catabolism and quality control and are subject …