Lysosomes play crucial roles in regulating cell metabolism, and K+ channels are critical for
controlling various aspects of lysosomal function. Additionally, lysosomal activity is essential …

Background and aims WNT signaling is central to spatial tissue arrangement, regulating
stem cell activity, and represents the hallmark of gastrointestinal cancers. While its role in …

Hematopoietic stem cells (HSCs) are an ideal source for the treatment of many
hematological diseases and malignancies, as well as diseases of other systems, because of …

Hematopoietic stem cells (HSCs) can self-renew and differentiate for the entire life of an
organism to produce new blood cells when needed. This process is regulated by …

Mitochondrial membrane potential (MMP) segregates functionally distinct subsets within
highly purified hematopoietic stem cells (HSCs). Here, we detail a protocol for FACS …

Loss of long-term haematopoietic stem cell function (LT-HSC) hampers the success of ex
vivo HSC gene therapy and expansion procedures, but the kinetics and the mechanisms by …

Loss of long-term hematopoietic stem cell (LT-HSC) function ex vivo hampers the success of
clinical protocols reliant on culture. However, the kinetics and mechanisms by which this …

Recent findings are challenging the classical hematopoietic model in which long-term
hematopoietic stem cells (LT-HSC) are the base of the hematopoietic system. Clonal …

Acute myeloid leukemia (AML) poses significant challenges in terms of prognosis and
treatment options. Leukemic stem cells (LSCs) contribute to therapy resistance, relapse and …

Hematopoietic stem cells are a group of heterogeneity cells with the potential to differentiate
into various types of mature blood cells. Their basic biological properties include …